Core--Bioinformatics

这个核心的主要目标是解剖和功能成像核心，为P01项目提供广泛的基于研究的成像技术;训练有素的专业成像医生，科学家和技术人员的复杂核心的支持;以及进行旨在改善多发性骨髓增生症（MM）诊断、预后通过临床和临床前研究进行治疗。这些目标将通过实现以下具体目标来实现：具体目标1。为骨髓瘤患者和动物模型提供解剖和功能成像。该核心将汇集最先进的解剖和功能成像资源，以提供必要的特定成像能力，使每个P01项目能够实现其各自的目标。这一令人印象深刻的技术支持将由一个由2名放射科医生组成的专门团队提供，并得到广泛的机构支持以及世界知名的顾问和合作者的协助。具体目标2。进行引导活检，对患者和动物模型、骨骼系统和软组织中的疾病分布进行快速准确的视觉评估。这项服务将使研究人员能够确定代谢最活跃的区域（前哨病变）。具体目标3。维护和关联解剖和功能成像研究的数据库。核心B将继续维护数据库（即，MRI扫描、骨骼调查、氟脱氧葡萄糖（FDG）PET扫描、CT结果等）在本供资周期内已经在使用的数据库，并根据需要建立新的数据库。数据库包含每项发现的定量结果， 专业成像专家认为与所涉及的模态相关。这些数据库定期转换为Excel电子表格格式，并通过电子邮件发送给癌症研究和生物统计提供商进行数据分析和关联，这一过程已经产生了 对多发性骨髓瘤生物学行为的许多新见解。因此，通过提供解剖和功能成像，以及数据库管理和与临床数据的相关性，Core B将使P01项目能够通过临床和临床前研究进行旨在改善MM诊断、预后和治疗的研究。

The primary objectives of this core, the Anatomic and Functional Imaging Core, are to provide P01 projects with an extensive array of research-based imaging technologies; the support of a sophisticated core of highly trained professional imaging physicians, scientists, and technologists; and the database maintenance and data correlation support required to pursue research aimed at improving multiple myelosis (MM) diagnosis, prognosis, and treatment through clinical and preclinical research. These objectives will be met through the accomplishment of the following specific aims: Specific Aim 1. Offer anatomic and functional imaging for myeloma patients and animal models. The core will bring together state-of-the-art anatomic and functional imaging resources to provide the specific imaging capabilities necessary to enable each P01 project to accomplish its individual aims. This impressive technological support will be delivered by a dedicated team of 2 radiologists with extensive institutional support and the assistance of consultants and collaborators who are world-renown in the modalities used. Specific Aim 2. Perform guided biopsies providing rapid and accurate visual assessment of disease distribution in patients and animal models, in the skeletal system, and in soft tissues. This service will allow investigators to identify the most metabolically active regions (sentinel lesions). Specific Aim 3. Maintain and correlate databases from anatomic and functional imaging studies. Core B will continue to maintain databases (i.e., MRI scans, skeletal surveys, fluorodeoxyglucose (FDG) PET scans, CT findings, etc.) already in use during the current funding cycle, and establish new databases as needed. Databases contain quantitative results of each finding that the professional imaging specialists feel is relevant for the modality involved. These databases are periodically converted to an Excel spreadsheet format and e-mailed to Cancer Research and Biostatistics providers for data analysis and correlation, a process that has already resulted in many new insights into the biological behavior of multiple myeloma. Thus, by providing anatomic and functional imaging, as well as database management and correlation with clinical data, Core B will enable P01 projects to pursue research aimed at improving MM diagnosis, prognosis, and treatment through clinical and preclinical research.