Solid polypeptide dosage forms for transdermal and subcutaneous administration

用于透皮和皮下给药的固体多肽剂型

• 批准号: 2428384
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2428384
• 关键词: Solid; polypeptide; dosage; forms; transdermal

The project aims to develop polypeptide (peptide and protein) formulations for transdermal and subcutaneous (sc) delivery. Model polypeptides will be formulated and processed with excipients that have been shown to stabilise proteins as solid particles. Drug loaded particles will be fabricated using emulsion and electrospraying processes. The excipients will include common polymers and low molecular weight molecules (e.g. buffers, amino acids). We will explore formulation and processing strategies to achieve controlled and extended release while maintaining polypeptide function. Dosage form design for administration of the solid, stabilised particles will be examined including microneedles for transdermal administration and as an subcutaneously injectable particle depot system.

该项目旨在开发用于经皮和皮下给药的多肽（肽和蛋白质）制剂。模型多肽将与已显示稳定蛋白质作为固体颗粒的赋形剂一起配制和加工。将使用乳液和电喷雾工艺制造载药颗粒。赋形剂将包括常见的聚合物和低分子量分子（例如缓冲剂、氨基酸）。我们将探索配方和加工策略，以实现控制和延长释放，同时保持多肽功能。将检查用于固体稳定颗粒给药的剂型设计，包括用于经皮给药的微针和作为皮下注射颗粒贮库系统。