Drug Reduction Intervention for Needle Exchange Clients

针交换客户的药物减少干预

• 批准号: 6800555
• 负责人: Robert Swift
• 金额: $ 39.25万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6800555
• 关键词: HIV infections; adult human (21+); behavior therapy; clinical research; cost effectiveness; disease /disorder proneness /risk; drug abuse therapy; human subject; human therapy evaluation; injection /infusion; interview; longitudinal human study; motivation; needle sharing; outcomes research; placebos; substance abuse related behavior

DESCRIPTION: (Applicant's Abstract) Injection drug users are at risk for a variety of problems such as HIV infection, hepatitis B and C, endocarditis, trauma, legal and work difficulties and family dysfunction. The objective of this research is to investigate ways to effectively reduce drug use among needle exchange program users, whose attendance at such services may signal the beginnings of risk reduction and a desire to escape drug use. In the past two decades brief interventions have proven to be promising in reducing substance abuse in a variety of settings. Recent developments in treatments for substance abuse underscore the primacy of utilizing motivation-based approaches. However, few studies have examined the likelihood that using a brief motivation based intervention with drug users enrolled in needle exchange programs may improve drug use outcomes. Intensifying brief intervention by adding a booster session might further enhance efficacy. The long-term objective of this programmatic body of treatment outcome research is to provide effective brief interventions for adult substance abusers. The specific aims of this proposal are to investigate the extent to which a Motivational Interview with a booster session is effective in reducing drug use among injection drug users enrolled in needle exchange programs as compared to an Attention Placebo Control (AQ condition in a 2-group design. Patients will be followed at 1-and 6 months after the baseline intervention, with self-reports confirmed by urine screens and reports of family or friends. Primary outcome variables include total number of drug use days and number of days in treatment. It is hypothesized that groups receiving MI will show lower levels of drug using days and more days of substance abuse treatment and that 2) the relationship between MI and the outcome variables will vary as a function of the patient's degree of readiness to change. This study will extend previous research by evaluating the use of MI with individuals who are needle exchange participants. The development of effective interventions for a population with poor linkage to primary care, an enormous burden of illness, and high HIV transmission risk should reduce the chronicity of drug use and enhance days in drug treatment.

描述：（申请人的摘要） 注射吸毒者面临诸如艾滋病毒等各种问题的风险 感染，乙型肝炎和C，心内膜炎，创伤，法律和工作困难 和家庭功能障碍。这项研究的目的是调查方法 有效地减少针头交换计划使用者的药物使用，他们 参加此类服务的出席可能标志着降低风险的开始和 渴望逃避吸毒。在过去的二十年中，简短干预措施有 事实证明，在各种环境中减少药物滥用方面是有希望的。 滥用药物治疗的最新发展强调了 利用基于动力的方法。但是，很少有研究检查 与吸毒者使用基于动机的简短干预的可能性 参加针头交换计划可​​以改善药物使用结果。 通过添加助推器会议来加强简短的干预可能会进一步 增强功效。 这项程序化治疗结果研究的长期目标 是为成人滥用者提供有效的简短干预措施。这 该提案的具体目的是调查一定程度的程度 通过助推器会议的励志访谈有效减少吸毒 在注册吸毒者中，与 注意安慰剂控制（2组设计中的AQ条件。患者将 在基线干预后的1和6个月紧随其后， 尿液屏幕和家人或朋友的报告证实了自我报告。 主要结果变量包括吸毒天数和数量 治疗的天数。假设接收MI的组将显示较低 使用天数和更多天的药物滥用治疗的药物水平，并且 2）MI和结果变量之间的关系将随着一个 患者准备改变程度的功能。 这项研究将通过评估MI的使用与 是针交换参与者的个人。有效的发展 与初级保健联系不佳的人群的干预措施，这是巨大的 疾病负担和高艾滋病毒传播风险应减少慢性 药物使用和增强药物治疗的天数。