Drug Reduction Intervention for Needle Exchange Clients

针交换客户的药物减少干预

• 批准号: 6800555
• 负责人: Robert Swift
• 金额: $ 39.25万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6800555
• 关键词: HIV infections; adult human (21+); behavior therapy; clinical research; cost effectiveness; disease /disorder proneness /risk; drug abuse therapy; human subject; human therapy evaluation; injection /infusion; interview; longitudinal human study; motivation; needle sharing; outcomes research; placebos; substance abuse related behavior

DESCRIPTION: (Applicant's Abstract) Injection drug users are at risk for a variety of problems such as HIV infection, hepatitis B and C, endocarditis, trauma, legal and work difficulties and family dysfunction. The objective of this research is to investigate ways to effectively reduce drug use among needle exchange program users, whose attendance at such services may signal the beginnings of risk reduction and a desire to escape drug use. In the past two decades brief interventions have proven to be promising in reducing substance abuse in a variety of settings. Recent developments in treatments for substance abuse underscore the primacy of utilizing motivation-based approaches. However, few studies have examined the likelihood that using a brief motivation based intervention with drug users enrolled in needle exchange programs may improve drug use outcomes. Intensifying brief intervention by adding a booster session might further enhance efficacy. The long-term objective of this programmatic body of treatment outcome research is to provide effective brief interventions for adult substance abusers. The specific aims of this proposal are to investigate the extent to which a Motivational Interview with a booster session is effective in reducing drug use among injection drug users enrolled in needle exchange programs as compared to an Attention Placebo Control (AQ condition in a 2-group design. Patients will be followed at 1-and 6 months after the baseline intervention, with self-reports confirmed by urine screens and reports of family or friends. Primary outcome variables include total number of drug use days and number of days in treatment. It is hypothesized that groups receiving MI will show lower levels of drug using days and more days of substance abuse treatment and that 2) the relationship between MI and the outcome variables will vary as a function of the patient's degree of readiness to change. This study will extend previous research by evaluating the use of MI with individuals who are needle exchange participants. The development of effective interventions for a population with poor linkage to primary care, an enormous burden of illness, and high HIV transmission risk should reduce the chronicity of drug use and enhance days in drug treatment.

描述：（申请人摘要） 注射毒品使用者面临各种问题的风险，如艾滋病毒 感染、B和C型肝炎、心内膜炎、创伤、法律的和工作困难 和家庭功能失调本研究的目的是探讨 为了有效地减少针头交换计划使用者的毒品使用， 参加这些服务可能标志着风险降低的开始， 渴望逃避毒品的使用。在过去的二十年里， 事实证明，在减少各种环境中的药物滥用方面很有希望。 药物滥用治疗的最新发展强调了以下方面的首要地位： 利用基于动机的方法。然而，很少有研究检查 对吸毒者进行基于动机的短暂干预 参加针头交换计划可能会改善药物使用的结果。 通过增加助推器会议来加强简短干预可能会进一步 增强功效。 这个治疗结果研究项目的长期目标是 是为成年药物滥用者提供有效的短暂干预。的 这项建议的具体目的是调查在多大程度上， 动机访谈与助推器会议是有效地减少药物使用 在参加针头交换方案的注射吸毒者中， 注意力安慰剂对照（AQ条件，2组设计）。患者将 在基线干预后1个月和6个月进行随访， 通过尿液筛查和家人或朋友的报告证实的自我报告。 主要结果变量包括药物使用天数和 天治疗。假设接受MI的组将显示出较低的 药物使用天数和药物滥用治疗天数的水平， 2)MI与结果变量之间的关系将随着时间的推移而变化。 患者的变化准备程度的函数。 这项研究将通过评估MI的使用来扩展以前的研究， 针具交换参与者。制定有效 对与初级保健联系不好的人口的干预， 疾病负担和高艾滋病毒传播风险应减少慢性病 提高吸毒率和戒毒天数。