Core--Vector

在该中心的当前周期中，病媒核心经历了实质性的演变，以利用在新型病毒载体方面取得的巨大进展。王丽丽博士是从Inder Verma博士的实验室招募来的，负责指挥矢量核心。在过去的四年里，向量核心提供的服务清单呈指数级增长。在最后一次续签赠款时，CORE提供了以腺病毒血清5型、腺相关病毒(AAV)血清2型和鼠为基础的生态和两性逆转录病毒为基础的载体服务。核心提供的服务清单已扩大到包括：基于人Ad5和至少5个猿腺病毒的腺病毒载体；基于人AAV血清型1、2和5以及猿AAV血清型7和8型的AAV载体，该列表扩大到 包括在下一个赠款周期内增加10个AAV血清型；慢病毒--至少6种基于艾滋病毒和FIV的不同伪型；以及小鼠逆转录病毒--各种伪型。

The Vector Core has undergone substantial evolution during the current cycle of the Center to leverage the tremendous progress that has been made in novel viral vectors. Dr. Lili Wang was recruited from Dr. Inder Verma's laboratory to direct the Vector Core. During the last four years, the list of services provided from the Vector Core has expanded exponentially. At the time of the last renewal of the grant the core provided services with vectors based on adenovirus serotype 5, adeno-associated virus (AAV) serotype 2 and murine based ecotropic and amphotropic retroviruses. The list of services provided by the core has expanded to include: Adenovirus - vectors based on human Ad5 and at least 5 simian adenoviruses; AAV- vectors based on the human AAV serotypes 1,2 and 5 and simian AAV serotype 7 and 8 with this list expanding to include 10 additional AAV serotypes over the next cycle of the grant; lentiviruses - at least 6 different pseudotypes based on HIV and FIV; and murine retroviruses - various pseudotypes.