CORE--VECTOR PRODUCTION

载体核心是宾夕法尼亚大学社区的关键资源，提供了广泛的基因转移技术。这个专门的机构由王丽丽博士运营，他在重组病毒方面拥有丰富的学术经验。核心已经收集了对发展载体有用的质粒、细胞系和病毒的全面清单。在重组病毒的设计、创造、生产和分析方面提供更全面的服务。许多载体系统可通过Core获得，包括鼠基逆转录病毒、腺病毒、腺相关病毒(AAV)和慢病毒。载体核心与宾夕法尼亚大学的重点实验室保持着密切的联系 参与了新型媒介的开发。相关的创新很快就会被引入到矢量核心中，在那里它们被验证并分发给教职员工。在此次P01的背景下，向量核心将发挥重要作用。核心将为所有三个项目提供媒介创建、扩展和纯化方面的服务。

The Vector Core is a critical resource to the Penn Community providing access to a wide array of gene transfer technology. This dedicated facility is run by Dr. Lili Wang, who has extensive academic based experience in recombinant viruses. The Core has assembled a comprehensive inventory of plasmids, cell lines, and viruses useful to the development of vectors. More comprehensive service is provided in the design, creation, production, and analysis of recombinant viruses. A number of vector systems are available through the Core, including murine-based retroviruses, adenoviruses, adeno-associated viruses (AAV), and lentiviruses. The Vector Core maintains strong links to key laboratories at University of Pennsylvania involved in novel vector development. Relevant innovations are quickly brought into the Vector Core, where they are validated and distributed to faculty. In the context of this P01, the Vector Core will play an important role. The Core will provide services in terms of vector creation, expansion and purification for all three projects.