Bioactive Bioresorbable Composites for Load Bearing Guided Bone Regeneration

为了在老龄化人口中保持生活质量，需要开发具有足够的机械性能以维持稳定的畸形矫正的生物可吸收椎间间隔物，以及促进通过间隔物的身体及时骨融合的成骨化学/结构。受控的生物吸收能力是导致椎体融合的主要健康骨，其长期健康不会受到与应力遮挡或硬金属或生物惰性聚合物椎体挤压相关的并发症的危害，而目前的技术可能发生这种情况。本研究的目的是基于新型聚乳酸技术研制一系列生物可吸收复合材料，其中含有硅酸盐替代羟基磷灰石颗粒用于成骨。除了复合材料样品的生产和材料特性外，这门课程还将包括生物降解谱的特性和对复合材料及其降解产物的生物响应的评估，以及对原型脊柱结构的力学评估。最终目标是开发一种新的骨诱导生物可吸收融合器系列。这一与行业相关的EPSRC-DTP案例学生将继续并扩大QM和Baxter Inc.之间的合作伙伴关系，其中包括开发Actifuse和InductiMigrate系列骨移植替代材料，该系列产品出现在2019年英国工程系列的皇家邮政邮票上。

To maintain quality of life in an aging population there is a need for development of bioresorbable intervertebral spacers with adequate mechanical properties to sustain a stable correction of deformity, and an osteogenic chemistry/structure to facilitate timely bone fusion through the body of the spacer. Controlled bioresorbability is required to result in vertebra fused predominantly by heathy bone, the long term health of which is not jeopardised by complications associated with stress shielding or extrusion of a stiff metallic or bio-inert polymeric vertebral body, as can occur with current technologies.The aim of this studentship is to formulate a series of bioresorbable composites based around novel PLA technology incorporating silicate-substitute hydroxyapatite particles for osteogenicity. Aside from the production and materials characterisation of composite samples this studentship would include characterisation of biodegradation profiles and assessment of the biological response to the composite materials and their degradation products in vitro, and mechanical evaluation of prototype vertebral structures. The ultimate goal being the development of a new line of osteoinductive bioresorbable fusion cages.This Industry linked EPSRC-DTP CASE studentship will continue and expand the collaborative partnership between QM and Baxter Inc. which includes development of the Actifuse and Inductigraft families of bone graft substitute materials, featured on a Royal Mail Stamp in the 2019 British Engineering Series.