Bioresorbable Zinc Staples for Anastomoses in the Digestive Tract

用于消化道吻合术的生物可吸收锌钉

• 批准号: 10560639
• 负责人: Yi-Xian Qin
• 金额: $ 62.97万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-03 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10560639
• 关键词: Alloys; Anastomosis - action; Animal Model; Anti-Bacterial Agents; Behavior; Biocompatible Materials; Biodegradation; Blood Vessels; Blood specimen; Body Fluids; Cell model; Cells; Characteristics; Child; Chronic; Clinical; Corrosion; Edema; Elasticity; Elements; Epithelial Cells; Excision; Extravasation; Fatigue; Fibroblasts; Foreign Bodies; Fracture; Gastric Juice; Gastrointestinal Surgical Procedures; Gastrointestinal tract structure; Generations; Goals; Growth; Hand; Hardness; Hemorrhage; Home; Image; Immersion; Implant; Implantation procedure; In Vitro; Infection; Inflammation; Intestines; Length of Stay; Life; Mechanics; Metals; Methods; Microbe; Miniature Swine; Mucous body substance; Natural regeneration; Nature; Operative Surgical Procedures; Outcome; Patients; Phase; Pilot Projects; Polymers; Procedures; Property; Provider; Resistance; Second Look Surgery; Series; Shapes; Skin Tissue; Specimen; Speed; Stomach; Structure; Surgical sutures; Surgical wound; Tensile Strength; Testing; Thick; Thinness; Time; Tissue Adhesives; Tissues; Titanium; Toxic effect; Vacuum; Veterinary Surgery; Zinc; antimicrobial; biodegradable polymer; biomaterial compatibility; clinical practice; design; fabrication; gastrointestinal; grasp; healing; hemocompatibility; implantation; improved; in vivo; innovation; intestinal juice; mechanical properties; melting; metallicity; natural antimicrobial; operation; recruit; response; restraint; screening; stem cell differentiation; stem cells; success; systemic toxicity; wound; wound closure; wound healing

Summary: For anastomoses in the digestive tract, titanium (Ti) staples are most-commonly used because of good mechanical strength and ductility but are not biodegradable. Their life-time presence may interfere with imaging examinations and impede growth especially in young patients. The long-term existence would also increase the chance of clinical complications such as leakage, stricture, chronic inflammation, foreign body response, bleeding and infection. A second revision/removal surgery must be performed if the situation gets worse. Biodegradable polymer materials such as PLA-PGA based staples are available but largely for subcuticular applications. Their poor mechanical properties restrain their applications in gastrointestinal (GI) anastomoses which need high closure strength. Thus, these identified inadequacies in the properties of Ti and polymer staples open opportunities for bioresorbable metal (i.e., zinc) as a new generation of anastomotic staples for the digestive tract. The use of metallic Zn as an alternative bioresorbable staple could offer some distinct advantages. The higher strength of Zn makes it ideal for GI anastomoses while its bioresorbable nature may minimize the chance of anastomotic leakage and stricture and will not impede growth or cause chronic inflammation, bleeding and infection. Plus, Zn is an essential and natural element for life, its toxicity should be of minimal concern. In fact, evidence showed that Zn implants could promote stem cell recruiting and differentiation. Zn is also a natural antimicrobial biomaterial that can minimize potential infection after surgical wound-closure as GI mucus is home to trillions of microbes. Additionally, their degradation speed and mechanical strength can be further manipulated through alloying. The goal hereby is to develop bioresorbable Zn-based staples for anastomoses in the digestive tract and to validate their efficacy in cells and animal models through biodegradation, biocompatibility, antimicrobial testing, stem cell differentiation, as well as wound healing including the GI mucus barrier regeneration.

概括： 对于消化道吻合术，最常使用钛 (Ti) 吻合钉，因为它具有良好的性能 机械强度和延展性，但不可生物降解。他们一生的存在可能会干扰 影像学检查并阻碍生长，尤其是年轻患者。长期存在就会 还会增加临床并发症的机会，如渗漏、狭窄、慢性炎症、 异物反应、出血和感染。必须进行第二次修复/切除手术 如果情况变得更糟。可生物降解的聚合物材料，例如基于 PLA-PGA 的短纤​​维 可用，但主要用于皮下应用。它们较差的机械性能限制了它们的 在需要高闭合强度的胃肠道（GI）吻合中的应用。因此，这些 钛和聚合物短纤维性能的不足为生物可吸收性带来了机遇 金属（即锌）作为新一代消化道吻合钉。金属的使用 锌作为替代生物可吸收材料可以提供一些独特的优势。强度越高 锌使其成为胃肠道吻合的理想选择，而其生物可吸收性质可以最大限度地减少 吻合口瘘和狭窄，不会阻碍生长或引起慢性炎症、出血 和感染。另外，锌是生命必需的天然元素，其毒性应该很小 忧虑。事实上，有证据表明，锌植入物可以促进干细胞的募集和 差异化。锌也是一种天然抗菌生物材料，可以最大限度地减少术后潜在感染 手术伤口闭合，因为胃肠道粘液是数万亿微生物的家园。此外，它们的退化 速度和机械强度可以通过合金化进一步控制。特此的目标是 开发用于消化道吻合术的生物可吸收锌基钉书钉并验证其 通过生物降解、生物相容性、抗菌测试、干细胞研究在细胞和动物模型中发挥功效 细胞分化以及伤口愈合，包括胃肠道粘液屏障再生。