Bioresorbable Zinc Staples for Anastomoses in the Digestive Tract

用于消化道吻合术的生物可吸收锌钉

• 批准号: 10560639
• 负责人: Yi-Xian Qin
• 金额: $ 62.97万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-03 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10560639
• 关键词: Alloys; Anastomosis - action; Animal Model; Anti-Bacterial Agents; Behavior; Biocompatible Materials; Biodegradation; Blood Vessels; Blood specimen; Body Fluids; Cell model; Cells; Characteristics; Child; Chronic; Clinical; Corrosion; Edema; Elasticity; Elements; Epithelial Cells; Excision; Extravasation; Fatigue; Fibroblasts; Foreign Bodies; Fracture; Gastric Juice; Gastrointestinal Surgical Procedures; Gastrointestinal tract structure; Generations; Goals; Growth; Hand; Hardness; Hemorrhage; Home; Image; Immersion; Implant; Implantation procedure; In Vitro; Infection; Inflammation; Intestines; Length of Stay; Life; Mechanics; Metals; Methods; Microbe; Miniature Swine; Mucous body substance; Natural regeneration; Nature; Operative Surgical Procedures; Outcome; Patients; Phase; Pilot Projects; Polymers; Procedures; Property; Provider; Resistance; Second Look Surgery; Series; Shapes; Skin Tissue; Specimen; Speed; Stomach; Structure; Surgical sutures; Surgical wound; Tensile Strength; Testing; Thick; Thinness; Time; Tissue Adhesives; Tissues; Titanium; Toxic effect; Vacuum; Veterinary Surgery; Zinc; antimicrobial; biodegradable polymer; biomaterial compatibility; clinical practice; design; fabrication; gastrointestinal; grasp; healing; hemocompatibility; implantation; improved; in vivo; innovation; intestinal juice; mechanical properties; melting; metallicity; natural antimicrobial; operation; recruit; response; restraint; screening; stem cell differentiation; stem cells; success; systemic toxicity; wound; wound closure; wound healing

Summary: For anastomoses in the digestive tract, titanium (Ti) staples are most-commonly used because of good mechanical strength and ductility but are not biodegradable. Their life-time presence may interfere with imaging examinations and impede growth especially in young patients. The long-term existence would also increase the chance of clinical complications such as leakage, stricture, chronic inflammation, foreign body response, bleeding and infection. A second revision/removal surgery must be performed if the situation gets worse. Biodegradable polymer materials such as PLA-PGA based staples are available but largely for subcuticular applications. Their poor mechanical properties restrain their applications in gastrointestinal (GI) anastomoses which need high closure strength. Thus, these identified inadequacies in the properties of Ti and polymer staples open opportunities for bioresorbable metal (i.e., zinc) as a new generation of anastomotic staples for the digestive tract. The use of metallic Zn as an alternative bioresorbable staple could offer some distinct advantages. The higher strength of Zn makes it ideal for GI anastomoses while its bioresorbable nature may minimize the chance of anastomotic leakage and stricture and will not impede growth or cause chronic inflammation, bleeding and infection. Plus, Zn is an essential and natural element for life, its toxicity should be of minimal concern. In fact, evidence showed that Zn implants could promote stem cell recruiting and differentiation. Zn is also a natural antimicrobial biomaterial that can minimize potential infection after surgical wound-closure as GI mucus is home to trillions of microbes. Additionally, their degradation speed and mechanical strength can be further manipulated through alloying. The goal hereby is to develop bioresorbable Zn-based staples for anastomoses in the digestive tract and to validate their efficacy in cells and animal models through biodegradation, biocompatibility, antimicrobial testing, stem cell differentiation, as well as wound healing including the GI mucus barrier regeneration.

总结： 对于消化道疾病，钛（Ti）斯台普斯是最常用的，因为它具有良好的 机械强度和延展性，但不可生物降解。他们一生的存在可能会干扰 影像学检查和阻碍生长，特别是在年轻患者中。长期存在， 也增加了临床并发症的机会，例如渗漏、狭窄、慢性炎症， 异物反应出血和感染必须进行第二次翻修/取出手术 如果情况变得更糟。可生物降解的聚合物材料，例如基于PLA-PGA的斯台普斯， 但主要用于表皮下应用。它们较差的机械性能限制了它们的 用于需要高闭合强度的胃肠道（GI）疾病。因此这些 已确定的钛和聚合物斯台普斯钉性能的不足为生物可吸收性 金属（即，锌）作为新一代消化道斯台普斯。使用金属 锌作为替代生物可吸收吻合钉可提供一些明显的优势。更高的强度 锌使其成为胃肠道疾病的理想选择，而其生物可吸收的性质可以最大限度地减少 吻合口瘘和狭窄，不会阻碍生长或引起慢性炎症、出血 和感染此外，锌是生命必需的天然元素，其毒性应是最小的 关心事实上，有证据表明，锌植入物可以促进干细胞招募， 分化锌也是一种天然的抗菌生物材料，可以最大限度地减少潜在的感染后， 胃肠道粘液是数万亿微生物的家园。此外，其降解 速度和机械强度可以通过合金化进一步控制。我们的目标是 开发生物可吸收的锌基斯台普斯，用于消化道中的糖尿病，并验证其 通过生物降解、生物相容性、抗微生物测试、干细胞、 细胞分化以及伤口愈合，包括GI粘液屏障再生。