Bioresorbable Zinc Staples for Anastomoses in the Digestive Tract

用于消化道吻合术的生物可吸收锌钉

• 批准号: 10560639
• 负责人: Yi-Xian Qin
• 金额: $ 62.97万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-03 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10560639
• 关键词: Alloys; Anastomosis - action; Animal Model; Anti-Bacterial Agents; Behavior; Biocompatible Materials; Biodegradation; Blood Vessels; Blood specimen; Body Fluids; Cell model; Cells; Characteristics; Child; Chronic; Clinical; Corrosion; Edema; Elasticity; Elements; Epithelial Cells; Excision; Extravasation; Fatigue; Fibroblasts; Foreign Bodies; Fracture; Gastric Juice; Gastrointestinal Surgical Procedures; Gastrointestinal tract structure; Generations; Goals; Growth; Hand; Hardness; Hemorrhage; Home; Image; Immersion; Implant; Implantation procedure; In Vitro; Infection; Inflammation; Intestines; Length of Stay; Life; Mechanics; Metals; Methods; Microbe; Miniature Swine; Mucous body substance; Natural regeneration; Nature; Operative Surgical Procedures; Outcome; Patients; Phase; Pilot Projects; Polymers; Procedures; Property; Provider; Resistance; Second Look Surgery; Series; Shapes; Skin Tissue; Specimen; Speed; Stomach; Structure; Surgical sutures; Surgical wound; Tensile Strength; Testing; Thick; Thinness; Time; Tissue Adhesives; Tissues; Titanium; Toxic effect; Vacuum; Veterinary Surgery; Zinc; antimicrobial; biodegradable polymer; biomaterial compatibility; clinical practice; design; fabrication; gastrointestinal; grasp; healing; hemocompatibility; implantation; improved; in vivo; innovation; intestinal juice; mechanical properties; melting; metallicity; natural antimicrobial; operation; recruit; response; restraint; screening; stem cell differentiation; stem cells; success; systemic toxicity; wound; wound closure; wound healing

Summary: For anastomoses in the digestive tract, titanium (Ti) staples are most-commonly used because of good mechanical strength and ductility but are not biodegradable. Their life-time presence may interfere with imaging examinations and impede growth especially in young patients. The long-term existence would also increase the chance of clinical complications such as leakage, stricture, chronic inflammation, foreign body response, bleeding and infection. A second revision/removal surgery must be performed if the situation gets worse. Biodegradable polymer materials such as PLA-PGA based staples are available but largely for subcuticular applications. Their poor mechanical properties restrain their applications in gastrointestinal (GI) anastomoses which need high closure strength. Thus, these identified inadequacies in the properties of Ti and polymer staples open opportunities for bioresorbable metal (i.e., zinc) as a new generation of anastomotic staples for the digestive tract. The use of metallic Zn as an alternative bioresorbable staple could offer some distinct advantages. The higher strength of Zn makes it ideal for GI anastomoses while its bioresorbable nature may minimize the chance of anastomotic leakage and stricture and will not impede growth or cause chronic inflammation, bleeding and infection. Plus, Zn is an essential and natural element for life, its toxicity should be of minimal concern. In fact, evidence showed that Zn implants could promote stem cell recruiting and differentiation. Zn is also a natural antimicrobial biomaterial that can minimize potential infection after surgical wound-closure as GI mucus is home to trillions of microbes. Additionally, their degradation speed and mechanical strength can be further manipulated through alloying. The goal hereby is to develop bioresorbable Zn-based staples for anastomoses in the digestive tract and to validate their efficacy in cells and animal models through biodegradation, biocompatibility, antimicrobial testing, stem cell differentiation, as well as wound healing including the GI mucus barrier regeneration.

摘要： 对于消化道吻合术，钛(钛)钉是最常用的，因为它具有良好的 机械强度和延展性，但不能生物降解。它们的终生存在可能会干扰 影像检查和阻碍生长发育，特别是在年轻患者。长期的存在将会 也增加了临床并发症的机会，如渗漏、狭窄、慢性炎症、 异物反应、出血和感染。必须进行第二次翻修/切除手术 如果情况变得更糟。可生物降解的聚合物材料，如聚乳酸-聚乙二醇酯基订书钉 可用，但主要用于皮下应用。它们较差的机械性能限制了它们的 在胃肠道(GI)吻合术中需要高闭合强度的应用。因此，这些 钛和聚合物短纤维性能上的不足为生物可再吸收提供了机会 金属(即锌)作为新一代消化道吻合口。金属材料的使用 锌作为一种可替代的生物可吸收主食可以提供一些明显的优势。更高的强度 锌使其成为胃肠道吻合术的理想材料，而其可生物吸收的性质可能会将 吻合口漏和狭窄，不会阻碍生长或引起慢性炎症、出血 和感染。另外，锌是生命所必需的天然元素，其毒性应该是最小的 担忧。事实上，有证据表明，植入锌可以促进干细胞招募和 差异化。锌也是一种天然的抗菌生物材料，可以将潜在的感染降至最低 手术伤口闭合，因为胃肠道粘液是数万亿微生物的家园。此外，它们的退化 速度和机械强度可以通过合金化进一步控制。在此，目标是 研制可生物吸收的锌基消化道吻合口，并验证其有效性。 在细胞和动物模型中通过生物降解、生物兼容性、抗菌试验、干细胞 细胞分化，以及伤口愈合，包括胃肠道粘液屏障再生。