Resistant E. coli in Humans and Poultry
人类和家禽中的耐药大肠杆菌
基本信息
- 批准号:6909507
- 负责人:
- 金额:$ 27.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-09-01 至 2006-08-31
- 项目状态:已结题
- 来源:
- 关键词:Escherichia coliEscherichia coli infectionsantibioticsbacterial geneticscephalosporinsclinical researchcommunicable disease transmissionconsumer productdrug resistanceeatingepidemiologyfecesfeces analysisfood contaminationfood processing /preparationgenotypehuman subjectphenotypepoultry productspublic healthquinolinesulfamethoxazoletrimethoprimvirulence
项目摘要
Background: Poultry products are the highest-risk foods for containing antibiotic-resistant and
extraintestinal-pathogenic E. coli. Whether such strains or their resistance elements are actually transmitted to consumers and, if so, pose a significant human health threat, is unknown.
Goals: Assess poultry contact and consumption as risk factors for human colonization with trimethoprim-sulfamethoxazole (TS)-, fluoroquinolone (FQ)-, and extended-spectrum cephalosporin (ESC)-resistant E. coli (i.e. TSREC, FQREC, and ESCREC), and define the degree of commonality among poultry-source versus human-source TSREC, FQREC, and ESCREC and their respective resistance elements.
Plans: Temporally-matched TSREC, FQREC, and ESCREC isolates from fecal samples from 629 human volunteers in four rural Midwestem communities, 160 retail poultry items fi'om the same locales, and local clinical microbiology laboratories will be compared. Risk factor analysis wi.ll identify epidemiological predictors of human colonization with TSREC, FQREC, and ESCREC, including contact with and consumption of poultry. Detailed molecular analysis will define the relationships between poultry-source and human-source isolates and their respective resistance elements, plus clarify the virulence potential for humans of poultry-source E. coll.
Relevance to the RFA: The proposal addresses Research Objective II of the RFA by helping implement Action Item #50 found in "A Public Health Action Plan to Prevent Antimic_:obial Resistance (Part I: Domestic Issues): Focus Area II, Prevention and Control": Conduct additional research to further define the effects of using various veterinary drugs on the emergence of resistant bacteria that infect or colonize food animals of different species, using various animal husbandry practices [indiirectly addressed]. Identify risk factors and preventive measures [addressed, for transmission to humans]. Assess the associated risk of. " Transmission of AR infections to humans [addressed]," Clinical disease in humans [addressed],' and Transfer
of resistance factors from animal flora to human flora [addressed]. Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes].
背景:禽类产品是风险最高的食品,含有抗生素耐药性和
肠外致病性大肠杆菌。目前尚不清楚这些菌株或其耐药成分是否真的会传播给消费者,如果是的话,是否会对人类健康构成重大威胁。
目标:评估家禽接触和消费作为人类定居的危险因素的甲氧普林-磺胺甲恶唑(TS)、氟喹诺酮(FQ)和耐超广谱头孢菌素(ESC)大肠杆菌(即TSREC、FQREC和ESCREC),并确定家禽源和人源TSREC、FQREC和ESCREC及其各自耐药元素的共同度。
计划:从中西部四个农村社区的629名人类志愿者的粪便样本中分离出时间上匹配的TSREC、FQREC和ESCREC分离物,来自相同地点的160件零售家禽物品,以及当地的临床微生物学实验室将进行比较。风险因素分析将确定人类在TSREC、FQREC和ESCREC中定居的流行病学预测因素,包括接触和食用家禽。详细的分子分析将确定禽源和人源分离株之间的关系及其各自的耐药元素,并澄清禽源E.coll对人类的毒力潜力。
与RFA的相关性:该提案针对RFA的研究目标II,通过帮助实施“预防抗药性的公共卫生行动计划:细菌耐药性(第一部分:国内问题):重点领域II,预防和控制”中的行动项目#50:进行额外的研究,以进一步确定使用各种兽药对感染或定居不同物种的食用动物的耐药细菌的出现的影响,使用各种畜牧业做法[间接处理]。确定风险因素和预防措施[已解决,传播给人类]。评估与之相关的风险。“AR感染向人类的传播[已解决],”人类的临床疾病[已解决],‘和转移
从动物菌群到人类菌群的抗性因素[已处理]。这项研究是否解决了当前迫切需要研究的、对公共卫生具有高度重要性的抗菌素耐药性问题?[是]。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JAMES R JOHNSON其他文献
JAMES R JOHNSON的其他文献
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{{ truncateString('JAMES R JOHNSON', 18)}}的其他基金
Infectious Disease Training in Clinical Investigation
临床研究中的传染病培训
- 批准号:
7694026 - 财政年份:2003
- 资助金额:
$ 27.42万 - 项目类别:
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