Evaluation of the Obesity Paradox in Diabetes: A Longitudinal Case-Control Study of Half a Million Patients

糖尿病肥胖悖论的评估：对 50 万名患者的纵向病例对照研究

• 批准号: nhmrc : 1063447
• 负责人: Dr Kerenaftali Klein
• 金额: $ 22.99万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/evaluation-obesity-paradox-million-patients/455058
• 关键词: Evaluation; Obesity; Paradox; Diabetes; Longitudinal

Obesity is a risk factor for developing diabetes. However, recent studies reported increased mortality risk associated with normal body weight in people with incident diabetes compared to overweight or obese patients. This “obesity paradox”, where being overweight appears to be protective, is new in diabetes. The mechanism behind this is not known. Using 20 years of follow-up data on 500,000 diabetes and control patients, this study proposes to find possible explanations behind obesity paradox.

肥胖是患糖尿病的危险因素。然而，最近的研究报告称，与超重或肥胖患者相比，糖尿病患者与正常体重相关的死亡风险增加。这种“肥胖悖论”——超重似乎具有保护作用——在糖尿病中是新出现的。这背后的机制尚不清楚。这项研究利用对 500,000 名糖尿病患者和对照患者 20 年的跟踪数据，旨在寻找肥胖悖论背后的可能解释。