The Obesity Paradox in Type 2 Diabetes

肥胖是患糖尿病的危险因素。然而，最近的研究报告，与超重或肥胖患者相比，糖尿病患者的正常体重增加了死亡风险。这种“肥胖悖论”，即超重似乎是保护性的，在糖尿病中是新的。这背后的机制尚不清楚。通过对50万名糖尿病患者和对照组患者20年的随访数据，本研究提出了肥胖悖论背后的可能解释。

Obesity is a risk factor for developing diabetes. However, recent studies reported increased mortality risk associated with normal body weight in people with incident diabetes compared to overweight or obese patients. This “obesity paradox”, where being overweight appears to be protective, is new in diabetes. The mechanism behind this is not known. Using 20 years of follow-up data on 500,000 diabetes and control patients, this study proposes to find possible explanations behind obesity paradox.