FMR Imaging of Eye Stabilization Processes

眼睛稳定过程的 FMR 成像

• 批准号: 6769507
• 负责人: CLAUDIO BUSETTINI
• 金额: $ 13.24万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6769507
• 关键词: Macaca mulatta; behavioral /social science research tag; computer program /software; computer system design /evaluation; electrophysiology; eye movements; functional magnetic resonance imaging; image processing; microelectrodes; motion perception; neural information processing; retinal bipolar neuron; stimulus /response; technology /technique development; vision tests; visual fields; visual perception; visual stimulus; visual tracking

DESCRIPTION: (Applicant's Abstract) Vision requires the images projected on the retina to remain stable. Visual eye-stabilization mechanisms detect perturbations of the retinal images and generate eye movements aimed at compensating for such disturbances. In humans and monkeys, with sophisticated foveal binocular vision, there are ultra-fast, highly specialized cortical eye-stabilization systems able to decode and compensate for the complex visual perturbations caused by the observer's own motion in a structured three-dimensional environment. The proposed pilot study will be centered on developing the technology and the experimental protocols needed for the functional magnetic resonance imaging (fMRI) of such processes in alert behaving monkeys and the acquisition of preliminary data on which a in-depth study proposal will then be developed. Extensive behavioral and single-unit studies in monkeys have shown that, even if cortical in origin, the neuronal activation and related oculomotor responses associated with such systems are closely time-locked to the stimulus onset and of machine-like repeatability. This makes them ideal for fMRI studies. Furthermore, there is strong evidence that such responses are generated by cortical areas directly linked to visual perception. A systematic manipulation of the visual stimuli can therefore be used to probe the underlying neuronal processes on which perception is then constructed. Their reflex-like nature will also be used as tool for the optimization of fMRI sequences and extraction algorithms, and the analysis of the temporal development of the fMRI signal, included the recently discovered "fast response". The matching of neuronal data from invasive studies with fMRI data obtained with identical protocols in the same animals will be an invaluable starting point for the interpretation of similar fMRI studies on humans. Comparative studies of those responses have highlighted almost astonishing similarities between the two species, suggesting a similar underlying neuronal structure. There are many open questions regarding the neuro anatomical and functional correspondences between monkeys and humans and the goal of this pilot study is to propose a novel, powerful tool for solving such issues of critical importance for the understanding of the human brain.

描述：（申请人的摘要）视觉需要投影在物体上的图像 视网膜保持稳定。视觉眼睛稳定机制检测 视网膜图像的扰动并产生旨在 补偿此类干扰。在人类和猴子中，具有复杂的 中心凹双眼视觉，有超快的、高度专业化的皮质 眼睛稳定系统能够解码和补偿复杂的视觉 由观察者自身运动引起的结构化扰动 三维环境。 拟议的试点研究将集中于开发技术和 功能磁共振成像所需的实验方案 (fMRI) 表现出警觉的猴子的此类过程以及获得 随后将根据初步数据制定深入研究提案。 对猴子进行的广泛的行为和单单位研究表明，即使 如果起源于皮质，则神经元激活和相关的动眼神经反应 与此类系统相关的神经元与刺激的开始时间密切相关，并且 类似机器的重复性。这使它们成为功能磁共振成像研究的理想选择。 此外，有强有力的证据表明，这种反应是由 与视觉感知直接相关的皮质区域。系统化的操纵 因此，视觉刺激的信号可用于探测潜在的神经元 然后构建感知的过程。他们的反射性质 还将用作功能磁共振成像序列和提取优化的工具 算法，以及功能磁共振成像信号的时间发展分析， 包括最近发现的“快速响应”。 将侵入性研究的神经元数据与获得的功能磁共振成像数据进行匹配 在相同的动物中使用相同的方案将是一个非常宝贵的开始 解释类似的人类功能磁共振成像研究的要点。比较 对这些反应的研究突显了几乎惊人的相似之处 这两个物种之间存在相似的神经元结构。 关于神经解剖学和功能有许多悬而未决的问题 猴子和人类之间的对应关系，这项试点研究的目标是 提出一种新颖、强大的工具来解决此类关键问题 对于理解人脑具有重要意义。