Burn depth profiling using photoacoustic analysis

使用光声分析进行烧伤深度分析

• 批准号: 6552471
• 负责人: John A. Viator
• 金额: $ 4.64万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2004-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6552471
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biosensor device; burn therapy; burns; clinical biomedical equipment; clinical research; diagnosis design /evaluation; diagnosis quality /standard; fiber optics; human subject; image processing; imaging /visualization /scanning; laboratory rat; lasers; mathematical model; noninvasive diagnosis; phantom model; photobiology; postdoctoral investigator; wound healing

DESCRIPTION (provided by applicant): Biomedical photoacoustics uses laser energy which is absorbed by tissue and transduced to a rapid thermal expansion so that the tissue becomes an active acoustic source. Using photoacoustics, burn wounds would be imaged, delineating the necrotic from viable tissue. The selective absorption of laser light by blood perfusion in the underlying viable tissue would give a depth map of the wound, using acoustic propagation time through the necrotic tissue. A photoacoustic probe will be designed and tested on tissue phantoms, animal models, and human subjects. The probe will consist of an optical fiber for laser light delivery and an acoustic sensor. The probe will scan the wound arid the signals will be analyzed using backprojection methods to derive a depth profile. This profile would allow clinical management of the wound, including optimal debridement of the necrotic tissue. The system will be non-invasive and provide a true image of the wound, something not currently available to the clinician.

描述（由申请人提供）：生物医学光声使用激光能量，激光能量被组织吸收并转换为快速热膨胀，使得组织成为有源声源。利用光声技术，可以对烧伤创面进行成像，从而将坏死组织与存活组织区分开来。通过下面的活组织中的血液灌注对激光的选择性吸收将使用通过坏死组织的声学传播时间给出伤口的深度图。将设计光声探头，并在组织模型、动物模型和人类受试者上进行测试。探头将由用于激光传输的光纤和声学传感器组成。探头将扫描伤口，并使用反投影方法分析信号以得出深度剖面。该轮廓将允许伤口的临床管理，包括坏死组织的最佳清创。该系统将是非侵入性的，并提供伤口的真实图像，这是目前临床医生无法获得的。