Characterizing C.elegans TGF-Beta pathway gene lon-2

表征秀丽隐杆线虫 TGF-Beta 通路基因 lon-2

• 批准号: 6640490
• 负责人: TINA L GUMIENNY
• 金额: $ 4.64万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2004-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6640490
• 关键词: Caenorhabditis elegans; biological signal transduction; developmental genetics; gene expression; green fluorescent proteins; phenotype; postdoctoral investigator; protein structure function; transforming growth factors

DESCRIPTION (provided by applicant): The transforming growth factor-beta (TGF-beta) signaling pathway is involved in many cellular processes ranging from proliferation, differentiation, development, and programmed cell death. Disruption of this pathway can result in a variety of diseases and is often an early step in the progression of cancers. The TGF-beta signaling pathway is highly conserved and is required in worms, flies, frogs, mice, and men. Since these growth factors work similarly in all of these organisms, what we learn about their function in simpler organisms should be relevant in other species, including humans. In this research project, I propose to explore the role of lon-2, a gene in C. elegans (a nematode worm), in the TGF-beta signaling pathway and its mechanism of action. My studies in this model organism should contribute to a better understanding of the signaling pathway in general and may provide for human therapies for TGF-beta-related diseases.

描述（由申请人提供）： 转化生长因子-β（TGF-β）信号传导途径参与许多细胞过程，包括增殖、分化、发育和程序性细胞死亡。这一途径的破坏可能导致各种疾病，并且通常是癌症进展的早期步骤。TGF-β信号通路是高度保守的，并且在蠕虫、苍蝇、青蛙、小鼠和人中是必需的。由于这些生长因子在所有这些生物体中的作用相似，我们在简单生物体中了解到的它们的功能应该与包括人类在内的其他物种有关。在本研究项目中，我打算探索lon-2基因在C. elegans（一种线虫），在TGF-β信号通路及其作用机制。我在这种模式生物中的研究应该有助于更好地理解一般的信号通路，并可能为TGF-β相关疾病的人类治疗提供帮助。

项目成果

Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling.

• DOI: 10.1371/journal.pgen.1000963
• 发表时间: 2010-05-20
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Gumienny TL;Macneil L;Zimmerman CM;Wang H;Chin L;Wrana JL;Padgett RW
• 通讯作者: Padgett RW

A small issue addressed.

解决了一个小问题。

• DOI: 10.1002/bies.10266
• 发表时间: 2003
• 期刊: BioEssays : news and reviews in molecular, cellular and developmental biology
• 作者: Gumienny,TinaL;Padgett,RichardW
• 通讯作者: Padgett,RichardW