GGL-RGS proteins: bifunctional G-protein regulators
GGL-RGS 蛋白:双功能 G 蛋白调节剂
基本信息
- 批准号:6630419
- 负责人:
- 金额:$ 4.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-08-01 至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant):
G-protein coupled receptors (GPCRs) regulate critical physiological processes such as neurotransmission, growth, and differentiation, and are also targeted by a large percentage of therapeutic agents and recreational drugs. Heterotrimeric guanine nucleotide binding proteins (G-proteins) act as molecular switches in GPCR pathways, in which the activity of the Ga subunit is determined by whether GTP or GDP is bound. Relative levels of GTP and GDP occupancy reflect the balance between nucleotide exchange and GTP hydrolysis. The former reaction is catalyzed by ligand activation of GPCRs coupled to heterotrimers, while the latter reaction is catalyzed by GTPase activating proteins, or GAPS. Regulators of G-protein Signaling (RGS) are diverse proteins that act as GAPs for Ga subunits. A subfamily of RGS proteins (RGS6, 7, 9, 11) contains a Gg-like (GGL) domain which mediates binding to b subunits. Therefore, in addition to interaction with GTP-Ga subunits through the RGS domain, GGL domain containing RGS (GGL-RGS) proteins may also associate with GDP-Ga subunits to promote receptor coupling. This project is designed to test the hypothesis that GGL-RGS proteins regulate both receptor coupling of GDP-Ga and GTP hydrolysis of GTP-Ga through the GGL and RGS domains, respectively, and that the alpha selectivity of the two domains determine the overall effect of GGL-RGS proteins on GPCR signaling. To test this hypothesis, the Ga selectivity of both the GUL and RGS domains will be determined, the molecular determinants of this selectivity will be defined, and wild type and mutant GGL-RGS constructs will be compared for their ability to regulate GPCR activation of effector pathways.
描述(由申请人提供):
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Shelley B Hooks其他文献
Interleukin-1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel-associated acute pain syndrome.
在紫杉醇相关的急性疼痛综合征期间,小胶质细胞释放的白介素-1β启动脊髓背角谷氨酸能活性的增强。
- DOI:
10.1002/glia.23557 - 发表时间:
2019 - 期刊:
- 影响因子:6.2
- 作者:
Xisheng Yan;Fen Li;Dylan W Maixner;Ruchi Yadav;Mei Gao;Mourad Wagdy Ali;Shelley B Hooks;Han-Rong Weng - 通讯作者:
Han-Rong Weng
Shelley B Hooks的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Shelley B Hooks', 18)}}的其他基金
Assay development and screening for small molecule RGS10 regulators to target neuroinflammation
针对神经炎症的小分子 RGS10 调节剂的测定开发和筛选
- 批准号:
9977073 - 财政年份:2019
- 资助金额:
$ 4.64万 - 项目类别:
Assay development and screening for small molecule RGS10 regulators to target neuroinflammation
针对神经炎症的小分子 RGS10 调节剂的测定开发和筛选
- 批准号:
9808243 - 财政年份:2019
- 资助金额:
$ 4.64万 - 项目类别:
Identification of Novel Nuclear RGS10 Binding Partners
新型核 RGS10 结合伴侣的鉴定
- 批准号:
9296748 - 财政年份:2017
- 资助金额:
$ 4.64万 - 项目类别:
Modulation of RGS proteins and Ovarian Cancer Chemoresistance
RGS 蛋白的调节和卵巢癌化疗耐药
- 批准号:
8323000 - 财政年份:2010
- 资助金额:
$ 4.64万 - 项目类别:
Modulation of RGS proteins and Ovarian Cancer Chemoresistance
RGS 蛋白的调节和卵巢癌化疗耐药
- 批准号:
7939178 - 财政年份:2010
- 资助金额:
$ 4.64万 - 项目类别:
Regulation of dopamine signaling by striatal RGS9-2; mechanisms and specificity
纹状体 RGS9-2 调节多巴胺信号传导;
- 批准号:
7012487 - 财政年份:2006
- 资助金额:
$ 4.64万 - 项目类别:
GGL-RGS proteins: bifunctional G-protein regulators
GGL-RGS 蛋白:双功能 G 蛋白调节剂
- 批准号:
6552268 - 财政年份:2002
- 资助金额:
$ 4.64万 - 项目类别:
相似海外基金
ROLE OF CELL ADHESION IN BIOLOGICAL SIGNAL TRANSDUCTION
细胞粘附在生物信号转导中的作用
- 批准号:
6238317 - 财政年份:1997
- 资助金额:
$ 4.64万 - 项目类别:
ROLE OF CELL ADHESION IN BIOLOGICAL SIGNAL TRANSDUCTION
细胞粘附在生物信号转导中的作用
- 批准号:
5210031 - 财政年份:
- 资助金额:
$ 4.64万 - 项目类别: