Catalytic Chirality Generation: New Strategies for Organic Synthesis

该项目将通过提供新的对映体选择方法来解决药物化学中的局部挑战。研究将在以下领域进行：(i) aza-Heck反应，（ii） C-C键激活过程，（iii）对映选择性氢化反应和（iv） C-N键激活过程。将调查各种各样的途径，并选择最有希望的线索进行发展。该项目将提供有机化学方面的广泛培训，学生将获得以下方面的经验：(1)方法开发，(2)机理研究，(3)目标定向合成。学生将精通高水平的实践和分析技能，包括空气敏感化学和复杂结构测定。研究结果将发表在顶级同行评审期刊上，并通过与潜在最终用户密切协商确保向工业界传播。学生将接受准备科学文件、发表科学报告和严格评估与合成实验相关的风险方面的培训。

The project will address topical challenges in medicinal chemistry through the provisions of new enantioselective methodologies. Research will be conducted in the areas and (i) aza-Heck reactions, (ii) C-C bond activation processes, (iii) enantioselective hydroarylation reactions and (iv) C-N bond activation processes. A wide range of avenues will be investigated and the most promising leads will be selected for development. The project will provide broad based training in organic chemistry and the student will gain experience in (i) methodology development, (ii) mechanistic studies, and (iii) target directed synthesis. The student will become proficient in high level practical and analytical skills, including air sensitive chemistry and complex structure determination. Results will be published in top level peer reviewed journals and dissemination to industry will be ensured by close consultation with potential end users. The student will receive training in the preparation of scientific documents, the delivery of scientific presentations and the rigorous assessment of risk associated with synthetic experiments.