New MRI techniques for cerebrovascular diseases

描述（由申请人提供）：Gregory W.阿尔伯斯的职业重点一直是在斯坦福大学医学中心以患者为导向的脑血管疾病研究。他的研究成就包括对中风诊断、治疗和预防领域的重大贡献。他还在制定脑血管疾病患者的国家临床实践指南方面发挥了重要作用。他是多名年轻中风研究人员的成功导师，他的八名学员目前在大学医学中心担任全职学术职务。阿尔伯斯博士目前的研究兴趣是评估新的MRI技术的实用性，特别是弥散和灌注MRI，作为急性卒中患者的诊断和治疗决策工具。K24奖将使他能够专注于促进几名初级临床研究人员的职业发展。该研究提案包括三个资助的NIH R01赠款。DEFUSE研究是一项由NIH资助的试点临床试验资助，旨在确定特定的患者亚组，由弥散和灌注MRI特征定义，这些患者在卒中症状发作后3至6小时内接受治疗时可能对静脉溶栓治疗有良好反应。这项初步试验将提供设计随机临床试验所需的基本数据，以确定根据特定MRI标准选择的卒中患者是否可以从卒中发作后3小时以上的静脉溶栓治疗中获益。DIAGNOSIS试验是一项为期4年、由NIH资助的单中心试验，旨在确定弥散和灌注MRI在出现提示脑缺血症状后72小时内出现的患者中的临床效用。第三个NIH资助的R01赠款将采用复杂的MRI技术来测量急性中风患者的脑灌注，并确定区分临界灌注不足水平和良性低血症的定量阈值。提出了一个创新的指导计划，将准备年轻的研究人员在临床研究的职业生涯。这个K24研究项目将扩展阿尔伯斯博士作为临床研究者的技能，并使他成为一个更有效的导师。

DESCRIPTION (provided by applicant): Dr. Gregory W. Albers' career focus has been patient-oriented research in cerebrovascular disease at Stanford University Medical Center. His research accomplishments include significant contributions to the fields of stroke diagnosis, treatment and prevention. He has also played a major role in developing national clinical practice guidelines for patients with cerebrovascular disease. He has been a successful mentor for multiple young stroke investigators and eight of his mentees currently hold full-time academic appointments at university medical centers. Dr. Albers' current research interest is evaluating the utility of new MRI techniques, particularly diffusion and perfusion MRI, as diagnostic and therapeutic decision making tools for patients with acute stroke. The K24 Award will allow him to focus his efforts on facilitating the career development of several junior clinical investigators. The research proposal consists of three funded NIH R01 grants. The DEFUSE study is an NIH funded pilot clinical trial grant that aims to identify specific patient subgroups, defined by diffusion and perfusion MRI profiles, who are likely to have a favorable response to intravenous thrombolytic therapy when treated between 3 and 6 hours after stroke symptom onset. This pilot trial will provide essential data needed to design a randomized clinical trial to determine whether stroke patients, selected with specific MRI criteria, can benefit from intravenous thrombolytic therapy beyond 3 hours after stroke onset. The DIAGNOSIS trial is a 4-year, single-center NIH funded trial designed to determine the clinical utility of diffusion and perfusion MRI in patients presenting within 72 hours of the onset of symptoms suggestive of brain ischemia. A third NIH funded R01 grant will employ sophisticated MRI techniques to measure cerebral perfusion in acute stroke patients and determine quantitative thresholds for differentiating critical levels of hypoperfusion from benign oligemia. An innovative mentoring program is proposed that will prepare young investigators for careers in clinical research. This K24 research program will expand Dr. Albers' skills as a clinical investigator and allow him to become a more effective mentor.