Improving Energy Cost Estimation of Physical Activity

描述(由申请人提供)： 通过这项申请，这项研究事业奖(K25)的候选人寻求在进行人类研究方面的额外培训，特别强调应用工程技术来改进自发体力活动(PA)的能量成本估计。他的近期目标是在生物医学研究和临床研究方面开发更多的专业知识；他的最终目标是开发一个独立的研究计划，评估PA和能量消耗(EE)，因为它与肥胖和代谢综合征有关。 自发性PA是总EE的重要组成部分。人们对坐、站和躺等日常活动的能量需求进行了广泛的研究。然而，许多自发活动的能量成本，如坐立不安和活动之间的转换，已知对能量平衡有实质性贡献，但尚未得到很好的研究和量化。重要的是要制定有效的方法来评估这些活动，以便完成准确的24小时环境影响评估。 这一应用的具体目的是：1)通过建立用于机械工作和能量成本计算的40个自发活动的数学模型，量化自发的PA，并改进自由生活个体的PA的能量成本估算。2)利用间接量热法和大作用力平台对上述模型和方法进行校准和验证。这些研究将提高现有技术对能源成本估计的总体准确性，并提供量化某些自发活动对能源消耗影响的技术。为有效、准确地评估日常生活质量提供了一种方便实用的方法。 能够获得每日PA的定量信息将有助于专家和医生制定和评估促进PA的战略，以改善健康和治疗肥胖症以及其他疾病。

DESCRIPTION (provided by applicant): Through this application, the candidate for this Research Career Award (K25) seeks additional training in conducting human research, with a special emphasis on applying engineering techniques to improve the estimation of energy cost of spontaneous physical activities (PA). His immediate goal is to develop additional expertise in biomedical research and clinical investigation; his ultimate goal is to develop an independent research program in assessment of PA and energy expenditure (EE) as it relates to obesity and the metabolic syndrome. Spontaneous PA is a significant part of total EE. Energy requirements of usual activities, such as sitting, standing and lying down have been studied extensively. However, the energy costs for many spontaneous activities, such as fidgeting and transitions between activities, which are known to substantively contribute to energy balance, have not been well studied and quantified. It is important to develop effective methods to assess those activities in order to complete accurate 24-hour EE assessment. The specific aims of this application are: 1) To quantify spontaneous PA and improve energy cost estimation of PA in free-living individuals by developing mathematical models of each of 40 spontaneous activities for mechanical work and energy cost calculation. 2) To calibrate and validate the above models and methods with subjects performing various activities using indirect calorimetry and a large force platform. These studies will improve the overall accuracy for energy cost estimation of the existing technology and provide the techniques to quantify the impact of certain spontaneous activity on energy expenditure. It also will provide a convenient and practical method to assess daily PA effectively and accurately. The ability to obtain quantitative information of daily PA will assist specialists and physicians in developing and evaluating strategies to promote PA for improving fitness and treating obesity as well as other diseases.