Nicotine Replacement and Counseling In Adolescents

青少年的尼古丁替代和咨询

• 批准号: 6785513
• 负责人: MARK L RUBINSTEIN
• 金额: $ 14.55万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6785513
• 关键词: adolescence (12-20); behavioral /social science research tag; clinical research; clinical trials; combination therapy; coping; counseling; data collection methodology /evaluation; depression; human subject; human therapy evaluation; longitudinal human study; nicotine replacement; outcomes research; personal log /diary; psychological stressor; questionnaires; smoking; smoking cessation; statistics /biometry; therapy compliance; tobacco abuse

DESCRIPTION (provided by applicant): Among addictive behaviors, tobacco smoking is the one most likely to become established during adolescence. Tobacco smoking is also one of the few preventable behaviors occurring during adolescence with direct results on adult morbidity and mortality. Among adolescents who smoke 10 or greater cigarettes per day, less than 20% report being successful at quitting and efforts to quit smoking are often hampered by withdrawal symptoms. The applicant is an Internist and specialist in Adolescent Medicine with expertise in the field of adolescent risk behaviors. The candidate's career objective is to both develop and implement new treatment strategies specifically for adolescents with a particular emphasis on tobacco cessation. During the training phase of the award, the applicant will have four primary development objectives: 1) to develop skills in the area of conducting clinical trails with a focus on the attainment of expertise specific to the study of adolescents; 2) to learn to recruit and follow large cohorts of adolescents; 3) to gain additional expertise in the qualitative and quantitative methodologies used for evaluating treatment outcomes and efficacy; and 4) to gain additional knowledge in the field of tobacco research and policy. These will be complimented by focused course work offered by the K30 funded Advanced Training in Clinical research Program at the UCSF. The research phase of the award will be to conduct a randomized controlled clinical trial comparing two methods of pharmacological smoking intervention among adolescents using data garnered from his preliminary studies on nicotine replacement and counseling in adolescents. This research will compare two different regimes that have been shown to be most efficacious in adults, for both adherence and efficacy in an adolescent population. The goals of this study are to: 1) determine the added benefit of nicotine replacement to that of counseling alone for smoking cessation in adolescents; 2) to determine which method of nicotine replacement (spray versus patch) may be superior with regards to quit rates and acceptability; 3) compare the level of adherence to each method; and 4) investigate correlations between pre-cessation cotinine levels and treatment outcome.

描述（由申请人提供）： 在成瘾行为中，吸烟是最有可能在青春期形成的行为。 吸烟也是发生在青少年时期的少数几种可预防的行为之一，直接导致成人发病率和死亡率。 在每天吸烟10支或更多的青少年中，不到20%的人报告成功戒烟，戒烟的努力往往受到戒断症状的阻碍。申请人是一名内科医生和青少年医学专家，在青少年危险行为领域具有专业知识。 候选人的职业目标是开发和实施专门针对青少年的新治疗策略，特别强调戒烟。 在该奖项的培训阶段，申请人将有四个主要发展目标： 1)培养开展临床试验领域的技能，重点是获得青少年研究的专门知识; 2）学习招募和跟踪大型青少年队列; 3）获得用于评估治疗结果和疗效的定性和定量方法的额外专业知识;以及4）获得烟草研究和政策领域的额外知识。这些将由K30资助的UCSF临床研究计划高级培训提供的重点课程工作予以补充。 该奖项的研究阶段将进行一项随机对照临床试验，比较青少年中两种药物吸烟干预方法，使用的数据来自他对青少年尼古丁替代和咨询的初步研究。 这项研究将比较两种不同的制度，已被证明是最有效的成年人，在青少年人口的依从性和疗效。 本研究的目的是：1）确定尼古丁替代对青少年戒烟单独咨询的额外益处; 2）确定哪种尼古丁替代方法（喷雾剂与贴片）在戒烟率和可接受性方面可能上级; 3)比较每种方法的依从性水平;以及4）调查戒烟前可替宁水平和治疗结果之间的相关性。