Viral Oncology Career Development Grant

个人描述(申请人提供)：我已经达到了职业生涯的一个阶段 我需要专注于我感兴趣的领域，病毒肿瘤学。因为我的 团契，我一直对与病毒相关的淋巴瘤感兴趣。 在我们的医疗中心有很多患有这些疾病的患者。艾滋病病毒 相关淋巴瘤很常见，迈阿密是HTLV-I的流行地区 因此，成人T细胞性白血病是常见病。我们有一个 最大的器官移植计划和许多移植后的病例 淋巴增生性疾病。我的重点一直是实验 治疗学，特别是某些病毒淋巴瘤如何在 对抗病毒药物的反应。这项工作已经产生了有希望的治疗方法 治疗病毒性淋巴瘤。我一直在研究它的机制 这些试剂在临床和实验室中的活性。我们发现了 不同的细胞凋亡途径被抗病毒药物激活 齐多夫定和干扰素α在疱疹病毒淋巴瘤中的应用。我们现在是 研究决定敏感性的细胞和病毒因素或 抵抗。我感兴趣的另一个领域是培训医生 病毒肿瘤学。我的培训补助金让我吸引了聪明的年轻人 医学博士S和医学博士S来到这个领域。每个研究员都在学习一项 病毒肿瘤学的特定领域。因为迈阿密是通往加勒比海的门户 以及南美，我计划与这些遭受重创的地区发展合作 由艾滋病和艾滋病相关癌症引起。我还将利用一项培训计划 对病毒肿瘤学感兴趣的非洲医生。我们已经确立了 基础设施来承担这些任务。职业环境 发展是极好的。我的上级同意解除我的所有职责 与研究、指导和职业发展无关。也许没有其他人了 医疗中心可以提供如此多样化的临床人群。我得到了支持 由临床和基础同行评审的基金和癌症中心作为一个项目 领袖。我还与我们的顶级科学家开展了合作，以 进一步加强我的计划。我近期的职业目标是确定 抗病毒介导的艾滋病淋巴瘤细胞凋亡机制及其研究进展 我们的病毒肿瘤学项目的临床和教育部分。我的龙 学期目标是将我们的病毒肿瘤学项目发展到我们被认可的地方 提供卓越的临床护理和研究，并将我们的学习扩展到拉丁语 美洲和非洲。我作为导师的角色还在继续。

DESCRIPTION (provided by applicant): I have reached a point in my career that requires singular dedication to my area of interest, viral oncology. Since my fellowship, I have been interested in lymphomas associated with viruses. There are many patients with these diseases at our medical center. HIV related lymphomas are common and Miami is an endemic area for HTLV-I therefore, Adult T Cell Leukemia is frequently seen. We have one of the largest organ transplant programs and there are many cases of post transplant lymphoproliferative disease. My emphasis has been on experimental therapeutics, specifically how certain viral lymphomas undergo apoptosis in response to antiviral agents. This work has resulted in promising treatments for viral lymphomas. I have continued to investigate the mechanisms of activity of these agents in the clinic and in the laboratory. We have found that distinct apoptotic pathways are activated by the antiviral agents Azidothymidine and Interferon alpha in herpes-virus Lymphomas. We are now investigating the cellular and viral factors which dictate sensitivity or resistance. My other area of interest is training physicians in the area of viral oncology. My training grant has allowed me to attract bright young M.D.'s and M.D./Ph.D.'s to this field. Each of the fellows is studying a specific area of viral oncology. Since Miami is the gateway to the Caribbean and South America, I plan to develop collaborations with these areas hard hit by AIDS and AIDS related cancers. I will also utilize a training program for African physicians interested in viral oncology. We have established infrastructures to undertake these tasks. The environment for career development is excellent. My superiors have agreed to free me of all duties unrelated to research, mentorship, and career development. Perhaps no other medical center could offer such a diverse clinical population. I am supported by clinical and basic peer reviewed funds and the cancer center as a program leader. I have also developed collaborations with our top scientists to further strengthen my program. My immediate career goal is to determine the mechanisms to antiviral mediated apoptosis in AIDS Lymphomas and develop the clinical and educational components of our viral oncology program. My long term goal is to develop our viral oncology program to where we are recognized for clinical care and research excellence and extend our studies to Latin America and Africa. My role as mentor is ongoing.