Viral Oncology Career Development Grant

病毒肿瘤学职业发展补助金

• 批准号: 6333297
• 负责人: William J Harrington
• 金额: $ 13.69万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-08 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6333297
• 关键词: AIDS related neoplasm /cancer; Epstein Barr virus; apoptosis; human herpesvirus 8; human tissue; interferon alpha; neoplasm /cancer pharmacology; nonHodgkin's lymphoma; tissue /cell culture; virus related neoplasm /cancer; zidovudine

DESCRIPTION (provided by applicant): I have reached a point in my career that requires singular dedication to my area of interest, viral oncology. Since my fellowship, I have been interested in lymphomas associated with viruses. There are many patients with these diseases at our medical center. HIV related lymphomas are common and Miami is an endemic area for HTLV-I therefore, Adult T Cell Leukemia is frequently seen. We have one of the largest organ transplant programs and there are many cases of post transplant lymphoproliferative disease. My emphasis has been on experimental therapeutics, specifically how certain viral lymphomas undergo apoptosis in response to antiviral agents. This work has resulted in promising treatments for viral lymphomas. I have continued to investigate the mechanisms of activity of these agents in the clinic and in the laboratory. We have found that distinct apoptotic pathways are activated by the antiviral agents Azidothymidine and Interferon alpha in herpes-virus Lymphomas. We are now investigating the cellular and viral factors which dictate sensitivity or resistance. My other area of interest is training physicians in the area of viral oncology. My training grant has allowed me to attract bright young M.D.'s and M.D./Ph.D.'s to this field. Each of the fellows is studying a specific area of viral oncology. Since Miami is the gateway to the Caribbean and South America, I plan to develop collaborations with these areas hard hit by AIDS and AIDS related cancers. I will also utilize a training program for African physicians interested in viral oncology. We have established infrastructures to undertake these tasks. The environment for career development is excellent. My superiors have agreed to free me of all duties unrelated to research, mentorship, and career development. Perhaps no other medical center could offer such a diverse clinical population. I am supported by clinical and basic peer reviewed funds and the cancer center as a program leader. I have also developed collaborations with our top scientists to further strengthen my program. My immediate career goal is to determine the mechanisms to antiviral mediated apoptosis in AIDS Lymphomas and develop the clinical and educational components of our viral oncology program. My long term goal is to develop our viral oncology program to where we are recognized for clinical care and research excellence and extend our studies to Latin America and Africa. My role as mentor is ongoing.

描述（由申请人提供）：我已经达到了我的职业生涯的一个点， 需要对我感兴趣的领域，病毒肿瘤学，做出特别的贡献 自从我 我一直对与病毒有关的淋巴瘤感兴趣。 在我们的医疗中心有许多患有这些疾病的患者。 艾滋病毒 相关的淋巴瘤是常见的，迈阿密是HTLV-1的流行区 因此，成人T细胞白血病是常见的。 我们有一个 最大的器官移植计划，有许多情况下，移植后 淋巴组织增生性疾病 我的重点是实验性的 治疗，特别是某些病毒性淋巴瘤如何经历细胞凋亡， 抗病毒药物的反应。 这项工作已经产生了有希望的治疗方法 治疗病毒性淋巴瘤 我一直在研究 这些药物在临床和实验室中的活性。 我们发现 抗病毒药物激活了不同的凋亡途径 疱疹病毒性淋巴瘤的叠氮胸苷和干扰素α。 我们现在 研究决定敏感性的细胞和病毒因素，或 阻力 我感兴趣的另一个领域是培训医生， 病毒肿瘤学 我的培训补助金让我能够吸引聪明的年轻人 M.D.和医学博士/博士到这个领域。 每个研究员都在研究一个 病毒肿瘤学的特定领域。 既然迈阿密是通往加勒比海的门户 和南美洲，我计划与这些遭受重创的地区发展合作关系， 艾滋病和艾滋病相关癌症。 我还将利用一个培训计划， 对病毒肿瘤学感兴趣的非洲医生。 我们建立 基础设施来完成这些任务。 职业环境 发展非常好。 我的上级已经同意免除我的一切职责 与研究、指导和职业发展无关。 也许没有其他 医疗中心可以提供如此多样化的临床人群。 我得到了支持 由临床和基本同行评审基金和癌症中心作为一个项目， 领袖 我还与我们的顶级科学家合作， 进一步加强我的计划。 我的职业目标是确定 艾滋病淋巴瘤中抗病毒介导的细胞凋亡的机制，并开发 我们的病毒肿瘤学项目的临床和教育部分。 我漫长 我们的长期目标是发展我们的病毒肿瘤学项目， 临床护理和研究卓越，并将我们的研究扩展到拉丁美洲 美洲和非洲。 我作为导师的角色还在继续。