Core--Hereditary Cancer Facility

遗传性癌症核心为Siteman癌症中心成员提供专业知识和支持服务，以解决和克服癌症遗传学研究的障碍。癌症遗传学研究往往很困难，因为有癌症史的家庭普遍缺乏参与，对遗传研究感到恐惧，高风险家庭的临床数据不足，以及难以招募不同种族的人口。 遗传性癌症核心组织提供广泛的服务： . 研究受试者招募的项目管理和协调 . 与华盛顿大学医学院（WUSM）人类研究委员会联络 . 癌症遗传学研究的设计与实现 . 临床风险评估和遗传咨询 . 医疗记录收集服务 此外，核心最近启动了一个被称为癌症免费控制倡议的项目，这是一个以圣路易斯社区为基础的项目，从65岁及以上没有癌症史的人那里收集2,000份带有相关健康和家族史信息的血液样本。DNA和血清样本将用于癌症病例对照研究。核心负责参与者招募、样本和数据收集以及数据库管理。组织采购中心主任Mark沃森负责处理遗传和蛋白质研究的样本。样本将提供给SCC研究人员批准的癌症研究方案。

The Hereditary Cancer Core provides Siteman Cancer Center members with expertise and support services to address and overcome barriers to cancer genetics research. Cancer genetics research is often difficult because of the general lack of participation from families with a history of cancer and fear of genetic research, inadequate clinical data for high-risk families, and difficulties in the recruitment of ethnically diverse populations. The Hereditary Cancer Core is organized to provide a broad range of services: . Project Management and Coordination of Study Participant Recruitment . Liaison with the Washington University School of Medicine (WUSM) Human Studies Committee . Design and Implementation of Cancer Genetics Research . Clinical Risk Assessment and Genetic Counseling . Medical Record Collection Service In addition, the core has recently launched a project referred to as the Cancer Free Controls Initiative, a St. Louis community based project to collect 2,000 blood samples with linked health and family history information from individuals 65 years of age and older who have no history of cancer. DNA and serum samples will be used in cancer case-control studies. The core is responsible for participant recruitment, specimen and data collection, and database management. Mark Watson, Director of the Tissue Procurement Core, processes the samples for genetic and protein studies. Samples will be made available to SCC investigators with approved cancer research protocols.