Core--Cognitive

在过去的六年里，慢性疾病认知核心研究中心的首要目标是促进慢性疾病研究中认知功能的测量。迄今为止，CRCD研究人员已经证明，认知问题与慢性医学疾病有着重要的相关性。我们已经证明，认知确实影响治疗方案的自我管理，而不依从性影响功能结局。我们还发现，传统的神经心理电池往往过于繁重的医疗患者和临床研究人员，生态有效的措施，这可能会更好地预测坚持在“真实的世界”的情况下，是很少的，缺乏特异性和可靠性，在预测治疗的依从性。慢性疾病研究人员的一个新的兴趣是疾病进展和治疗过程中认知功能的轨迹。另一个新出现的兴趣是认知（和心理）成熟度对青少年接受干预和坚持治疗方案的影响。因此，在此更新申请中，我们将更具体地关注测量认知和心理功能，因为它们会影响治疗依从性。具体而言，我们的目标是：1）继续 鼓励和支持在所有CRCD研究项目中使用专门定制的测试组合测量认知和心理功能。我们将针对青少年和成年人。2)检查认知功能在更广泛的治疗方案中的影响（例如，每日多次用药，生活方式的改变），并更加关注随着疾病进展和治疗而发生的认知功能变化。3)在适当的时候，利用已发表的、经过验证的浓缩神经心理学测试组合，以减少患者和研究人员的负担，同时获得有关慢性疾病人群认知功能的有意义和有效的数据。4)设计和试验更生态合理的认知功能措施，特别是因为它可能影响治疗依从性。在本申请中，我们提出了 支持这些目标的背景和重要性信息以及我们建议用于实现这些目标的方法。

The overarching goal of the Center for Research in Chronic Disorders Cognitive Core over the past six years has been to facilitate the measurement of cognitive function in chronic illness research. CRCD researchers, to date, have demonstrated that cognitive problems are significant correlates of chronic medical disorders. We have shown that cognition does affect self-management of treatment regimens and that non-adherence affects functional outcomes. We have also found that traditional neuropsychological batteries are often too burdensome for medical patients and clinical researchers and that ecologically valid measures, which might better predict adherence in "real world" situations, are few and lack specificity and reliability in predicting treatment adherence. An emerging interest among researchers in chronic disorders is the trajectory of cognitive function over the course of disease progression and treatment. Another emerging interest is in the impact of cognitive (and psychological) maturity on adolescents' receptivity to interventions and adherence to treatment regimens. Thusly, in this renewal application, we will focus more specifically on measuring cognitive and psychological function as they impact on treatment adherence. Specifically, our goals are to: 1) Continue to encourage and support measurement of cognitive and psychological function, with specifically tailored test batteries, in all CRCD research projects. We will target adolescent as well as adult populations. 2) Examine the impact of cognitive function in a wider variety of treatment regimens (e.g. multiple daily medications, lifestyle changes) and with an increased focus on change in cognitive function with disease progression and treatment. 3) Utilize published, validated condensed neuropsychological test batteries, when appropriate, to decrease patient and researcher burden while yielding meaningful and valid data on cognitive function in the chronic disorder population. 4) Design and pilot more ecologically sound measures of cognitive function, specifically as it may impact on treatment adherence. We present, in this application, the background and significance information to support these goals and the methodology we propose using to achieve them.