Core--Cognitive

在过去的六年里，慢性疾病认知核心研究中心的首要目标是促进慢性疾病研究中认知功能的测量。迄今为止，CRCD的研究人员已经证明，认知问题与慢性疾病有显著的相关性。我们已经证明，认知确实会影响治疗方案的自我管理，而不遵守治疗方案会影响功能结果。我们还发现，对于病人和临床研究人员来说，传统的神经心理学电池往往过于繁重，而且在预测治疗依从性方面，生态学上有效的措施很少，而且缺乏特异性和可靠性，这些措施可能更好地预测“现实世界”情况下的依从性。慢性疾病研究人员的一个新兴兴趣是认知功能在疾病进展和治疗过程中的轨迹。另一个新出现的兴趣是认知（和心理）成熟度对青少年接受干预和坚持治疗方案的影响。因此，在这个更新应用中，我们将更具体地关注于测量认知和心理功能，因为它们对治疗依从性的影响。具体来说，我们的目标是：1)继续

The overarching goal of the Center for Research in Chronic Disorders Cognitive Core over the past six years has been to facilitate the measurement of cognitive function in chronic illness research. CRCD researchers, to date, have demonstrated that cognitive problems are significant correlates of chronic medical disorders. We have shown that cognition does affect self-management of treatment regimens and that non-adherence affects functional outcomes. We have also found that traditional neuropsychological batteries are often too burdensome for medical patients and clinical researchers and that ecologically valid measures, which might better predict adherence in "real world" situations, are few and lack specificity and reliability in predicting treatment adherence. An emerging interest among researchers in chronic disorders is the trajectory of cognitive function over the course of disease progression and treatment. Another emerging interest is in the impact of cognitive (and psychological) maturity on adolescents' receptivity to interventions and adherence to treatment regimens. Thusly, in this renewal application, we will focus more specifically on measuring cognitive and psychological function as they impact on treatment adherence. Specifically, our goals are to: 1) Continue to encourage and support measurement of cognitive and psychological function, with specifically tailored test batteries, in all CRCD research projects. We will target adolescent as well as adult populations. 2) Examine the impact of cognitive function in a wider variety of treatment regimens (e.g. multiple daily medications, lifestyle changes) and with an increased focus on change in cognitive function with disease progression and treatment. 3) Utilize published, validated condensed neuropsychological test batteries, when appropriate, to decrease patient and researcher burden while yielding meaningful and valid data on cognitive function in the chronic disorder population. 4) Design and pilot more ecologically sound measures of cognitive function, specifically as it may impact on treatment adherence. We present, in this application, the background and significance information to support these goals and the methodology we propose using to achieve them.