Core--Cognitive

在过去的六年里，慢性疾病认知核心研究中心的首要目标是促进慢性病研究中认知功能的测量。到目前为止，CRCD的研究人员已经证明，认知问题是慢性医学疾病的重要相关因素。我们已经证明，认知确实影响治疗方案的自我管理，而不坚持治疗方案会影响功能结果。我们还发现，传统的神经心理学电池对内科患者和临床研究人员来说往往负担过重，而且在预测治疗依从性方面，可能更好地预测治疗依从性的生态有效指标很少，而且缺乏特异性和可靠性。慢性疾病研究人员的一个新兴趣是疾病进展和治疗过程中认知功能的轨迹。另一个新出现的兴趣是认知(和心理)成熟度对青少年接受干预和坚持治疗方案的影响。因此，在此次续签申请中，我们将更具体地关注认知和心理功能对治疗依从性的影响。具体来说，我们的目标是：1)继续 在所有CRCD研究项目中，鼓励和支持认知和心理功能的测量，并使用专门定制的测试组。我们将以青少年和成年人为目标。2)在更广泛的治疗方案(例如，每日多种药物治疗、改变生活方式)中检查认知功能的影响，并更加关注随着疾病进展和治疗而发生的认知功能变化。3)在适当的情况下，利用已发表的、经过验证的浓缩神经心理学测试组件来减轻患者和研究人员的负担，同时产生关于慢性疾病人群认知功能的有意义和有效的数据。4)设计和试行更生态合理的认知功能措施，特别是因为它可能会影响治疗依从性。在此应用程序中，我们呈现 支持这些目标的背景和意义信息，以及我们建议用来实现这些目标的方法。

The overarching goal of the Center for Research in Chronic Disorders Cognitive Core over the past six years has been to facilitate the measurement of cognitive function in chronic illness research. CRCD researchers, to date, have demonstrated that cognitive problems are significant correlates of chronic medical disorders. We have shown that cognition does affect self-management of treatment regimens and that non-adherence affects functional outcomes. We have also found that traditional neuropsychological batteries are often too burdensome for medical patients and clinical researchers and that ecologically valid measures, which might better predict adherence in "real world" situations, are few and lack specificity and reliability in predicting treatment adherence. An emerging interest among researchers in chronic disorders is the trajectory of cognitive function over the course of disease progression and treatment. Another emerging interest is in the impact of cognitive (and psychological) maturity on adolescents' receptivity to interventions and adherence to treatment regimens. Thusly, in this renewal application, we will focus more specifically on measuring cognitive and psychological function as they impact on treatment adherence. Specifically, our goals are to: 1) Continue to encourage and support measurement of cognitive and psychological function, with specifically tailored test batteries, in all CRCD research projects. We will target adolescent as well as adult populations. 2) Examine the impact of cognitive function in a wider variety of treatment regimens (e.g. multiple daily medications, lifestyle changes) and with an increased focus on change in cognitive function with disease progression and treatment. 3) Utilize published, validated condensed neuropsychological test batteries, when appropriate, to decrease patient and researcher burden while yielding meaningful and valid data on cognitive function in the chronic disorder population. 4) Design and pilot more ecologically sound measures of cognitive function, specifically as it may impact on treatment adherence. We present, in this application, the background and significance information to support these goals and the methodology we propose using to achieve them.