An investigation of the Fluid-Structure Interaction in articular cartilage across disparate scales

不同尺度关节软骨流固相互作用的研究

• 批准号: 2435099
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2435099
• 关键词: investigation; Fluid; Structure; Interaction; articular

This project will bring together multiple components to effectively describe the Fluid-Structure Interaction of cartilage across disparate scales. A critical path toward the coupling of simulations at different scales, experimental validation, and clinical relevance will be ascertained and specific focus placed on modelling aspects where necessary. The desired outcomes are: - A 3D microscopic model of immersed fibrous networks which accurately describes the behaviour of cartilage. Selection of the comprising viscoelastic solid structure by exploring simple Hookean springs, semi-flexible polymers, and biopolymers; - Delineated parameter regimes of microscale models from which the necessary terms in the continuum equations of macroscale poroelasticity can be faithfully described. Determine the separation of scales required and investigate a range of mechanisms to facilitate coupling; - Validation of model predictions by experimentation of cartilage samples under load. Extend current laboratory protocol for compression testing of poroelastic materials to cartilage. Perform measurements of load versus displacement for operating conditions representative of natural joints; - Uptake by clinicians of the techniques developed under their guidance, enhance the current technology used for the treatment of joint health; - A framework that can be modified to investigate other systems of interest related to fluid flow through deformable porous materials.

该项目将汇集多个组件，以有效地描述不同尺度的软骨的流固相互作用。将确定不同规模的模拟耦合、实验验证和临床相关性的关键路径，并在必要时特别关注建模方面。期望的结果是： - 浸入式纤维网络的 3D 微观模型，准确描述软骨的行为。通过探索简单的胡克弹簧、半柔性聚合物和生物聚合物来选择包含粘弹性固体结构； - 描绘微观模型的参数范围，从中可以忠实地描述宏观孔隙弹性连续方程中的必要项。确定所需的尺度分离并研究一系列促进耦合的机制； - 通过在负载下对软骨样本进行实验来验证模型预测。将多孔弹性材料压缩测试的当前实验室协议扩展到软骨。对代表自然接缝的操作条件进行负载与位移的测量； - 临床医生采用在他们的指导下开发的技术，增强当前用于治疗关节健康的技术； - 一个可以修改的框架，用于研究与通过可变形多孔材料的流体流动相关的其他感兴趣的系统。