CORE--Cell Signaling Research Core

CORE--细胞信号研究核心

• 批准号: 6750894
• 负责人: JOHN J REINERS
• 金额: $ 4.11万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6750894
• 关键词: biological signal transduction; biomedical facility; cellular pathology; environmental exposure; environmental health; environmental toxicology; protein kinase; second messengers; tissue /cell culture

Description (provided by applicant): The function of a cell, tissue, or organism is dependent upon the coordinate interplay of myriad processes. This interplay involves intra- and extracellular signaling or communication. "Signal transduction" is a generic term used to describe diverse processes involved in intra- and extra-cellular communication. In essence, signal transduction entails the mechanisms whereby a cell receives an internal or external stimulus/message and activates/inactivates effectors whose engagement result in a perturbation of cellular homeostasis. Thus, the phenotype, characteristics and function of a cell/organism are highly dependent upon signal transduction processes. Signal transduction research is very germane to the field of toxicology because many toxicants disrupt the coordinate interplay of signaling pathways. They do so by modulating the production of "second messenger? molecules or the activities of signaling effectors. Knowledge of signaling networks, their interplay with one another, and the biological processes they affect is useful in predicting and defining both mode of action, and consequences of toxicant exposure. Such knowledge is also useful in defining strategies to modulate the consequences of toxicant exposure, and the subsequent development of acute illness/injury or disease. The overall mission of the Cell Signaling & Function (CSF) Research Core is to encourage and facilitate the interaction and collaboration of Center scientists who have interests in understanding the mediators, modulators and mechanisms of signal transduction in toxicant-perturbed, normal, and neoplastic cells and tissues, and to relate these signaling processes to cellular function and ultimately to human health. The broad based goals of the CSF Research core are to: 1) maintain a functional, interactive group of scientists who have interests in signal transduction research, 2) provide a focus for research interactions (i.e., collaborations) on topics involving toxicants, signaling and cell function, with emphasis on those that affect human health, 3) develop and maintain a contemporary intellectual and technical expertise that is a resource to Center members and other University investigators; and 4) facilitate the translation of mechanistic "bench" research and insights into application toward human populations through intra- and inter-programmatic interactions and collaborations.

描述（由申请人提供）：细胞、组织或生物体的功能取决于无数过程的协调相互作用。这种相互作用涉及细胞内和细胞外信号或通信。“信号转导”是用于描述涉及细胞内和细胞外通讯的不同过程的通用术语。本质上，信号转导需要细胞接收内部或外部刺激/信息并激活/灭活效应物的机制，所述效应物的参与导致细胞稳态的扰动。因此，细胞/生物体的表型、特征和功能高度依赖于信号转导过程。信号转导研究与毒理学领域密切相关，因为许多毒物破坏了信号通路的协调相互作用。它们通过调节“第二信使”的产生来做到这一点。分子或信号效应物的活性。信号网络的知识，它们之间的相互作用，以及它们影响的生物过程，在预测和确定有毒物质暴露的作用模式和后果方面是有用的。这些知识也有助于制定战略，以调节毒物接触的后果，以及随后发生的急性疾病/损伤或疾病。Cell Signaling &的总体使命 功能（CSF）研究核心是鼓励和促进中心科学家的互动和合作，他们有兴趣了解毒物干扰，正常和肿瘤细胞和组织中信号转导的介质，调节剂和机制，并将这些信号传导过程与细胞功能并最终与人类健康联系起来。CSF研究核心的广泛目标是：1）维持对信号转导研究感兴趣的科学家的功能，互动小组，2）提供研究互动的焦点（即，合作）的主题涉及毒物，信号和细胞功能，重点是那些影响人类健康，3）发展和保持当代的知识和技术专长，这是一个资源，中心成员和其他大学的研究人员;和4）促进翻译的机械“板凳”研究和见解，通过内部和跨计划的应用对人类群体 互动和协作。