CORE--Cell Signaling Research Core

描述（由申请人提供）：细胞、组织或有机体的功能依赖于无数过程的协调相互作用。这种相互作用包括细胞内和细胞外的信号或通讯。“信号转导”是一个通用术语，用于描述细胞内和细胞外通信所涉及的各种过程。从本质上讲，信号转导涉及细胞接收内部或外部刺激/信息并激活/灭活效应物的机制，这些效应物的参与导致细胞稳态的扰动。因此，细胞/生物体的表型、特征和功能高度依赖于信号转导过程。信号转导研究与毒理学领域密切相关，因为许多毒物破坏信号通路的协调相互作用。它们通过调节“第二信使”的产生来实现这一点。分子或信号效应器的活动。了解信号网络，它们之间的相互作用，以及它们影响的生物过程，对于预测和定义作用模式以及毒物暴露的后果都是有用的。这些知识也有助于制定策略，以调节毒物接触的后果，以及随后急性疾病/损伤或疾病的发展。《细胞信号与通讯》的总体任务

Description (provided by applicant): The function of a cell, tissue, or organism is dependent upon the coordinate interplay of myriad processes. This interplay involves intra- and extracellular signaling or communication. "Signal transduction" is a generic term used to describe diverse processes involved in intra- and extra-cellular communication. In essence, signal transduction entails the mechanisms whereby a cell receives an internal or external stimulus/message and activates/inactivates effectors whose engagement result in a perturbation of cellular homeostasis. Thus, the phenotype, characteristics and function of a cell/organism are highly dependent upon signal transduction processes. Signal transduction research is very germane to the field of toxicology because many toxicants disrupt the coordinate interplay of signaling pathways. They do so by modulating the production of "second messenger? molecules or the activities of signaling effectors. Knowledge of signaling networks, their interplay with one another, and the biological processes they affect is useful in predicting and defining both mode of action, and consequences of toxicant exposure. Such knowledge is also useful in defining strategies to modulate the consequences of toxicant exposure, and the subsequent development of acute illness/injury or disease. The overall mission of the Cell Signaling & Function (CSF) Research Core is to encourage and facilitate the interaction and collaboration of Center scientists who have interests in understanding the mediators, modulators and mechanisms of signal transduction in toxicant-perturbed, normal, and neoplastic cells and tissues, and to relate these signaling processes to cellular function and ultimately to human health. The broad based goals of the CSF Research core are to: 1) maintain a functional, interactive group of scientists who have interests in signal transduction research, 2) provide a focus for research interactions (i.e., collaborations) on topics involving toxicants, signaling and cell function, with emphasis on those that affect human health, 3) develop and maintain a contemporary intellectual and technical expertise that is a resource to Center members and other University investigators; and 4) facilitate the translation of mechanistic "bench" research and insights into application toward human populations through intra- and inter-programmatic interactions and collaborations.