Training Program in Molecular and Cellular Toxicology

分子和细胞毒理学培训计划

• 批准号: 6593640
• 负责人: JOHN J REINERS
• 金额: $ 6.13万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6593640
• 关键词: Training; Program; Molecular; Cellular; Toxicology

DESCRIPTION (provided by applicant) The consequences of human exposure to environmental and occupational toxicants are a global issue. Over time, the field of toxicology has come to recognize the relationship between chronic low dose exposure, and the development of disease. With the emergence of molecular and cellular biology, recombinant DNA technology, bioinformatics, and molecular genetics, biomedical science has become more complex and interdisciplinary. Unique opportunities exist to relate environmentally caused disorders to genetic, biochemical and molecular mechanisms. Therefore, it is important to train current and future scientists in the technologies of today's science, and give them the scientific foundation that will enable them to use the technologies to address environmental health issues. The Institute of Environmental Health Sciences (IEHS) is a free-standing unit within the organizational structure of Wayne State University with a focus on molecular, cellular, and genomic approaches to the study of toxicant effects. As the headquarters of a NIEHS P30-supported Environmental Health Science (EHS) Center, the IEHS functions as a focal point for stimulating, developing and coordinating instruction in toxicology, and studying the relationship between environmental factors and human disease. The IEHS is also the headquarters of an interdisciplinary pre-doctoral program in Molecular and Cellular Toxicology. The 11 faculty associated with this training program are drawn from the IEHS and the EHS Center. This T32 grant will focus on the training of 2-predoctoral students in the Molecular and Cellular Toxicology Program. The training of students selected from this interdisciplinary graduate program will be augmented by a 2-3 year appointment to the NIEHS-sponsored training grant. These students will receive intensive instruction such that they: 1) are versed in the principals of toxicology but recognize the cross disciplinary nature of the field; 2) gain expertise with many of the contemporary techniques and technologies used in the life sciences; and 3) recognize and appreciate the complex relationships between environment, genetics/genomics, susceptibility to toxicants, and the development and progression of human disease. The overall goal of the predoctoral program in Molecular and Cellular Toxicology is to develop independent scientists who are well prepared for environmental health research, and equipped to perform competitive research using contemporary concepts, approaches and the technologies of molecular biology, cell biology, genomics and genetics. It is envisioned that students with such training will be better equipped to pursue postdoctoral research at major research laboratories throughout the United States.

说明(申请人提供)人类接触环境和职业毒物的后果是一个全球性问题。随着时间的推移，毒理学领域逐渐认识到慢性低剂量暴露与疾病发展之间的关系。随着分子和细胞生物学、重组DNA技术、生物信息学和分子遗传学的出现，生物医学科学变得更加复杂和交叉。存在着将环境引起的疾病与遗传、生化和分子机制联系起来的独特机会。因此，重要的是培训当前和未来的科学家掌握当今科学的技术，并为他们提供科学基础，使他们能够利用这些技术来解决环境健康问题。环境健康科学研究所(IEHS)是韦恩州立大学组织结构中的一个独立单位，专注于分子、细胞和基因组方法来研究有毒物质的影响。作为NIEHS P30支持的环境健康科学(EHS)中心的总部，IEHS的职能是激励、发展和协调毒理学教学，并研究环境因素与人类疾病之间的关系。IEHS也是分子和细胞毒理学跨学科博士前项目的总部。与该培训计划相关的11名教职员工来自IEHS和EHS中心。这笔T32助学金将专注于分子和细胞毒理学项目中2名博士前学生的培训。从这一跨学科研究生计划中挑选出来的学生的培训将通过NIEHS赞助的培训补助金的2-3年聘任来加强。这些学生将接受密集的指导，使他们：1)精通毒理学原理，但认识到该领域的跨学科性质；2)获得许多现代技术和生命科学中使用的技术的专业知识；3)认识和理解环境、遗传学/基因组学、毒物易感性和人类疾病的发展和进展之间的复杂关系。分子和细胞毒理学博士前项目的总体目标是培养独立的科学家，他们为环境健康研究做好充分准备，并具备利用当代分子生物学、细胞生物学、基因组学和遗传学的概念、方法和技术进行竞争性研究的能力。据设想，接受这种培训的学生将更好地准备在美国各地的主要研究实验室从事博士后研究。