Diabetes and Endocrinology Research Center

描述（由申请人提供）： 我们寻求在哥伦比亚大学建立一个糖尿病和内分泌学研究中心。DERC将促进Naomi Berrie糖尿病中心、纽约肥胖研究中心的糖尿病、免疫学、移植和肥胖研究小组以及哥伦比亚大学的动脉硬化/脂质研究历史上最强大的小组之间的互动。我们设想，这些相互作用将扩展到目前正在进行结构生物学、基因组学、并发症、细胞生物学基础研究的群体，以及身体成分、能量消耗、青少年2型糖尿病遗传流行病学、胰岛移植和预防糖尿病并发症等领域的临床研究人员。DERC将通过扩大导师和实验室的范围，加强国家卫生研究院在内分泌学、代谢学、儿科学、动脉硬化症、免疫学、遗传学和肥胖症方面的现有培训赠款，以使受训者受益。为了实现这些目标，DERC将在六个研究领域提供核心服务：激素/代谢物，蛋白质表达，免疫学/细胞库，基因组学，身体成分和组织代谢物的分析测定，以及小鼠表型。此外，DERC将为哥伦比亚大学其他研究领域的知名科学家提供进入糖尿病领域的机会和鼓励，并将通过模仿现有Naomi Berrie奖学金的试点/可行性资助计划为年轻研究人员提供初始资金。DERC将通过旨在提高哥伦比亚大学和纽约市科学/学术界对糖尿病研究的认识的项目丰富活动，以及通过与大纽约地区其他学术机构更广泛的互动，扩大研究基础。

DESCRIPTION (provided by applicant): We seek to establish a Diabetes and Endocrinology Research Center at Columbia University. The DERC will promote interactions among research groups in diabetes, immunology, transplantation and obesity at the Naomi Berrie Diabetes Center, The New York Obesity Research Center, and the historically strong groups in arteriosclerosis/lipid research at Columbia University. We envision that these interactions will extend to groups currently pursuing basic research in structural biology, genomics, complications, cell biology and clinical investigators in the areas of body composition, energy expenditure, genetic epidemiology of type 2 diabetes in adolescents, islet transplantation and prevention of diabetes complications. The DERC will strengthen existing NIH training grants in Endocrinology, Metabolism, Pediatrics, Arterioeclerosis, Immunology, Genetics and Obesity by broadening the pool of mentors and laboratories for the trainees' benefit. To meet these goals, the DERC will provide core services in six areas of research: Hormone/metabolite, Protein expression, Immunology/cell banking, Genomics, Analytical determinations of body composition and tissue metabolites, and Mouse phenotyping. Additionally, the DERC will provide opportunity and encouragement for established scientists in other research areas at Columbia University to enter the diabetes field, and will make available initial funding for young investigators through a pilot/feasibility grant program modeled after the existing Naomi Berrie Fellowship Award. The DERC will broaden the research base through program enrichment activities aimed at increasing the awareness of diabetes research in the scientific/academic community of Columbia University and New York City and through more extensive interactions with other academic institutions in the greater New York area.