Longevity and reproduction in Drosophila

果蝇的寿命和繁殖

• 批准号: 6829879
• 负责人: Jadwiga M Giebultowicz
• 金额: $ 7.08万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-15 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6829879
• 关键词: Drosophilidae; arthropod genetics; biological clocks; circadian rhythms; functional /structural genomics; gender difference; gene expression; genetic regulation; genetically modified animals; heat; longevity; oxidative stress; proteins; reproduction; starvation

DESCRIPTION (provided by applicant): As life span increases in the US population and more women choose demanding careers deferring childbearing to later years, age-related health problems become a matter of national concern. There is an urgent need to understand the biological basis of the aging process and the basis of reproductive senescence in humans. Research on model organisms such as Drosophila helped to uncover several lifespan-regulating genes; however, genetic pathways that postpone aging are far from being fully understood. We recently discovered that the gene period (per), a well-known component of the biological clock, affects longevity and fertility in female Drosophila. There is extensive knowledge of this gene and its protein product; therefore, tools are available to research its role in aging. We plan to verify and expand our initial findings and address several new questions: 1) Are per effects on lifespan gender-specific? 2) Does per affect reproduction and life span in both virgin and mated females? 3) Which physiological systems are involved in per action? Results of these proposed studies will provide the first insights into the mechanisms underlying the action of the clock gene period in the investigated phenotype and allow us to develop a research project grant (R01) aimed at understanding the molecular pathways underpinning female reproductive aging. Our goal is consistent with NIA plans to accelerate efforts to discover additional longevity-related genes and to characterize their biological function. Given the conserved functions of per in biological timing from flies to humans, knowledge gained concerning the mechanism of action of this gene may provide important contributions to our understanding of reproductive and chronological aging in humans.

描述（由申请人提供）：随着美国人口的寿命增加，越来越多的妇女选择要求职业将生育延迟到以后的几年，与年龄相关的健康问题成为国家关注的问题。迫切需要了解衰老过程的生物学基础和人类生殖衰老的基础。对果蝇等模型生物的研究有助于发现了几个寿命调节基因。但是，延迟衰老的遗传途径远非充分理解。我们最近发现，生物时钟的众所周知的基因（PER）会影响雌性果蝇的寿命和生育能力。 对该基因及其蛋白质产物有广泛的了解。因此，可以使用工具来研究其在衰老中的作用。我们计划验证和扩展我们的初始发现并解决几个新问题：1）对寿命特定的寿命特定效果吗？ 2）在处女和交配的女性中，每个影响繁殖和寿命是否会影响？ 3）每个动作涉及哪些生理系统？这些提出的研究的结果将提供有关调查表型中时钟基因周期作用的基础机制的首次见解，并使我们能够开发旨在了解女性生殖老化的分子途径的研究项目赠款（R01）。我们的目标与NIA计划一致，以加速努力，以发现额外的寿命相关基因并表征其生物学功能。鉴于从蝇到人类的生物时机的保守功能，就该基因的作用机理而获得的知识可能会为我们对人类生殖和年代衰老的理解提供重要贡献。