Balkan Nephropathy: Environmental/Clinical Epidemiology

巴尔干肾病：环境/临床流行病学

• 批准号: 6776393
• 负责人: PLAMEN S DIMITROV
• 金额: $ 5.4万
• 依托单位: BULGARIA NTL CTR OF PUBLIC HLTH PROTECTN
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-23 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6776393
• 关键词: Europe; age difference; anemia; atomic absorption spectrometry; clinical research; colorimetry; creatinine; disease /disorder etiology; environmental exposure; environmental toxicology; epidemiology; genetic susceptibility; heavy metals; human subject; international cooperation; kidney disorder; kidney disorder diagnosis; longitudinal human study; major histocompatibility complex; morphology; pathologic process; patient oriented research; questionnaires; rural area; ultrasound; urinalysis

DESCRIPTION (provided by applicant) This application responds to RFA-TW-02-002 "Global Health Research Initiative Program For New Foreign Investigators". The Principal Investigator successfully completed his training under an NIH D43 Program (ITREOH), Number 2 D43 TW00641-06, in May 2001, at Michigan State University (MSU) for a Master's Degree in Epidemiology and research on Balkan Endemic Nephropathy (BEN). The PI returned to his country in May 2001 and presently has an appointment with the National Center of Hygiene, Medical Ecology and Nutrition (NCHMEN), Sofia, Bulgaria. In the NCHMEN, he occupies the position of the Head of Epidemiology Laboratory, and he is entrusted with the task of developing the field of Epidemiology. Currently he continues his research on BEN and publishes extensively. His training at MSU, under NIH 2 D43 TW00641-06, and continuing collaboration with MSU will greatly facilitate his task in developing an epidemiology program (training and research) at the NCHMEN and the greater Sofia, and his BEN research. We propose to conduct research on Balkan Endemic Nephropathy in Vratza district, Bulgaria. BEN is a disease, which affects people only in rural areas in Balkan countries, including Vratza district, Bulgaria. In the region, the disease is still a mystery and risk factors remain putative. There is a need to identify the etiology of the disease in order to possibly prevent its development. BEN runs asymptomatically, and, as a result, it is diagnosed at its latest stages. Diagnostic criteria are not well established. There is a need to identify the clinical development in the early stages of the disease, which will help for timely detection and possibly treatment. The proposed work would provide critical information for early detection and a scientific base for the diagnostic criteria of Balkan Endemic Nephropathy. Through this project, we expect to improve our knowledge about diagnostic criteria and early markers of BEN. Thus, we will contribute to the detection of the disease, which is predominant in women - 2/3 of cases are women. At the environmental level, we will identify whether some natural toxicants present in the environment in the region contribute to the development of BEN, and whether these are associated with any early markers of the disease. The proposed grant would strengthen collaboration between the Principal Investigator and his former U.S. scientific mentors.

描述（由申请人提供） 此应用程序响应 RFA-TW-02-002“新外国研究者全球健康研究计划”。首席研究员于 2001 年 5 月在密歇根州立大学 (MSU) 成功完成了 NIH D43 计划 (ITREOH)（编号 2 D43 TW00641-06）的培训，获得巴尔干地方性肾病 (BEN) 流行病学和研究硕士学位。 PI 于 2001 年 5 月返回祖国，目前在保加利亚索非亚国家卫生、医学生态和营养中心 (NCHMEN) 任职。在NCHMEN，他担任流行病学实验室主任，肩负着发展流行病学领域的重任。目前他继续对 BEN 进行研究并发表了大量文章。他在密歇根州立大学根据 NIH 2 D43 TW00641-06 接受的培训以及与密歇根州立大学的持续合作将极大地促进他在 NCHMEN 和大索非亚制定流行病学计划（培训和研究）的任务以及他的 BEN 研究。 我们提议在保加利亚弗拉察地区开展巴尔干地方性肾病研究。 BEN 是一种疾病，仅影响巴尔干国家农村地区的人们，包括保加利亚的弗拉察地区。在该地区，这种疾病仍然是一个谜，危险因素仍然是假定的。需要确定该疾病的病因，以便可能预防其发展。 BEN 运行无症状，因此在最新阶段才被诊断出来。诊断标准尚未明确。需要在疾病的早期阶段确定临床发展，这将有助于及时发现和可能的治疗。拟议的工作将为巴尔干地方性肾病的早期检测提供关键信息，并为巴尔干地方性肾病的诊断标准提供科学基础。通过这个项目，我们希望提高对 BEN 诊断标准和早期标志物的了解。因此，我们将为这种疾病的发现做出贡献，这种疾病在女性中占主导地位 - 2/3 的病例是女性。在环境层面，我们将确定该地区环境中存在的一些天然毒物是否会导致 BEN 的发生，以及这些物质是否与该疾病的任何早期标志物相关。拟议的拨款将加强首席研究员和他的前美国科学导师之间的合作。