Balkan Nephropathy: Environmental/Clinical Epidemiology

巴尔干肾病：环境/临床流行病学

• 批准号: 7107237
• 负责人: PLAMEN S DIMITROV
• 金额: $ 5.27万
• 依托单位: BULGARIA NTL CTR OF PUBLIC HLTH PROTECTN
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-23 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7107237
• 关键词: Europe; age difference; anemia; atomic absorption spectrometry; clinical research; colorimetry; creatinine; disease /disorder etiology; environmental exposure; environmental toxicology; epidemiology; genetic susceptibility; heavy metals; human subject; international cooperation; kidney disorder; kidney disorder diagnosis; longitudinal human study; major histocompatibility complex; morphology; pathologic process; patient oriented research; questionnaires; rural area; ultrasound; urinalysis

DESCRIPTION (provided by applicant) This application responds to RFA-TW-02-002 "Global Health Research Initiative Program For New Foreign Investigators". The Principal Investigator successfully completed his training under an NIH D43 Program (ITREOH), Number 2 D43 TW00641-06, in May 2001, at Michigan State University (MSU) for a Master's Degree in Epidemiology and research on Balkan Endemic Nephropathy (BEN). The PI returned to his country in May 2001 and presently has an appointment with the National Center of Hygiene, Medical Ecology and Nutrition (NCHMEN), Sofia, Bulgaria. In the NCHMEN, he occupies the position of the Head of Epidemiology Laboratory, and he is entrusted with the task of developing the field of Epidemiology. Currently he continues his research on BEN and publishes extensively. His training at MSU, under NIH 2 D43 TW00641-06, and continuing collaboration with MSU will greatly facilitate his task in developing an epidemiology program (training and research) at the NCHMEN and the greater Sofia, and his BEN research. We propose to conduct research on Balkan Endemic Nephropathy in Vratza district, Bulgaria. BEN is a disease, which affects people only in rural areas in Balkan countries, including Vratza district, Bulgaria. In the region, the disease is still a mystery and risk factors remain putative. There is a need to identify the etiology of the disease in order to possibly prevent its development. BEN runs asymptomatically, and, as a result, it is diagnosed at its latest stages. Diagnostic criteria are not well established. There is a need to identify the clinical development in the early stages of the disease, which will help for timely detection and possibly treatment. The proposed work would provide critical information for early detection and a scientific base for the diagnostic criteria of Balkan Endemic Nephropathy. Through this project, we expect to improve our knowledge about diagnostic criteria and early markers of BEN. Thus, we will contribute to the detection of the disease, which is predominant in women - 2/3 of cases are women. At the environmental level, we will identify whether some natural toxicants present in the environment in the region contribute to the development of BEN, and whether these are associated with any early markers of the disease. The proposed grant would strengthen collaboration between the Principal Investigator and his former U.S. scientific mentors.

描述(由申请人提供) 此应用程序响应RFA-TW-02-002“针对新的外国调查人员的全球健康研究倡议计划”。首席调查员于2001年5月在密歇根州立大学(MSU)成功地完成了他在NIH D43计划(ITREOH)下的培训，该计划编号2 D43 TW00641-06，获得了巴尔干地方性肾病(BEN)流行病学和研究硕士学位。他于2001年5月回国，目前与保加利亚索非亚的国家卫生、医疗生态和营养中心(NCHMEN)有约。在NCHMEN，他担任流行病学实验室负责人，并肩负着发展流行病学领域的任务。目前，他继续着对本的研究，并发表了大量的著作。根据NIH 2 D43 TW00641-06，他在密歇根州立大学接受的培训，以及与密歇根州立大学的持续合作，将极大地促进他在NCHMEN和大索非亚制定流行病学计划(培训和研究)的任务，以及他的BEN研究。我们建议在保加利亚Vratza地区开展巴尔干地方性肾病研究。本病是一种疾病，只影响巴尔干国家农村地区的人们，包括保加利亚的Vratza区。在该地区，这种疾病仍然是一个谜，风险因素仍然是推定的。有必要确定疾病的病因，以便可能防止其发展。本没有任何症状，因此，它在最新阶段被诊断出来。诊断标准还没有建立得很好。有必要在疾病的早期阶段确定临床发展，这将有助于及时发现和可能的治疗。拟议的工作将为早期发现提供重要信息，并为巴尔干地方性肾病的诊断标准奠定科学基础。通过这个项目，我们希望提高我们对BEN的诊断标准和早期标志物的了解。因此，我们将为发现该疾病做出贡献，该疾病在女性中占主导地位--三分之二的病例是女性。在环境层面，我们将确定该地区环境中存在的一些天然毒物是否有助于BEN的发展，以及这些毒物是否与疾病的任何早期标志有关。拟议的拨款将加强首席调查员和他的前美国科学导师之间的合作。

项目成果

Incidence and predictive factors of Balkan endemic nephropathy: a longitudinal study.

巴尔干地方性肾病的发病率和预测因素：一项纵向研究。

• DOI: 10.4103/1319-2442.128539
• 发表时间: 2014
• 期刊: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
• 作者: Hanjangsit,Kesinee;Dimitrov,PlamenS;Zhang,Hongmei;Batuman,Vecihi;Burch,Jim;Tzolova,SvetlaD;Karmaus,WilfriedJ
• 通讯作者: Karmaus,WilfriedJ

Clinical markers in adult offspring of families with and without Balkan Endemic Nephropathy.

患有和不患有巴尔干地方性肾病的家庭成年后代的临床标志物。

• DOI: 10.1038/sj.ki.5000120
• 发表时间: 2006
• 期刊: Kidney international
• 影响因子: 19.6
• 作者: Dimitrov,P;Tsolova,S;Georgieva,R;Bozhilova,D;Simeonov,V;Bonev,A;Karmaus,W
• 通讯作者: Karmaus,W

Increased blood pressure in adult offspring of families with Balkan endemic nephropathy: a prospective study.

巴尔干地方性肾病家族成年后代血压升高：一项前瞻性研究。

• DOI: 10.1186/1471-2369-7-12
• 发表时间: 2006
• 期刊: BMC nephrology
• 影响因子: 2.3
• 作者: Dimitrov,PlamenS;Simeonov,ValeriA;Tsolova,SvetlanaD;Bonev,AngelG;Georgieva,RossitzaB;Karmaus,WilfriedJ
• 通讯作者: Karmaus,WilfriedJ

Offspring of parents with Balkan Endemic Nephropathy have higher C-reactive protein levels suggestive of inflammatory processes: a longitudinal study.

患有巴尔干地方性肾病的父母的后代具有较高的 C 反应蛋白水平，提示炎症过程：一项纵向研究。

• DOI: 10.1186/1471-2369-10-10
• 发表时间: 2009
• 期刊: BMC nephrology
• 影响因子: 2.3
• 作者: Karmaus,Wilfried;Dimitrov,Plamen;Simeonov,Valeri;Tsolova,Svetla;Batuman,Vecihi
• 通讯作者: Batuman,Vecihi

Reduced kidney size in adult offspring of Balkan endemic nephropathy patients and controls: a prospective study.

巴尔干地方性肾病患者和对照成年后代的肾脏尺寸减小：一项前瞻性研究。

• DOI: 10.1097/maj.0b013e3181e2353e
• 发表时间: 2010
• 期刊: The American journal of the medical sciences
• 作者: Hanjangsit,Kesinee;Dimitrov,Plamen;Karmaus,Wilfried;Batuman,Vecihi;Simeonov,Valeri;Bonev,Angel;Tsolova,Svetla
• 通讯作者: Tsolova,Svetla