ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE

描述（由申请方提供）：识别和缓解疼痛是实验动物医学中的常见挑战，并且是《动物福利法》和《实验动物使用公共卫生服务政策》规定的。 然而，关于啮齿动物有效术后镇痛的可用数据主要通过研究大鼠收集;相对较少的研究专门评估小鼠临床使用的镇痛疗效。 小鼠兽医医学管理的临床方法的发展落后于转基因小鼠品系的可用性和科学使用的爆炸性扩展，特别是在需要手术操作的研究中其重要性日益增加。如果美国农业部最终修改其对“动物”的定义，将Mus属包括在内，那么确定小鼠有效镇痛方案的需求将变得更加迫切。 本申请旨在评价几种口服镇痛剂方案治疗小鼠急性、手术和炎性疼痛的疗效。 通过饮用水口服给药镇痛药物在研究环境中是有利的，因为它允许大量动物得到有效治疗，而无需额外的操作。 然而，重要的考虑因素是确保治疗方案对动物正在经历的疼痛有效，并且动物自愿消耗足够的药物以达到有效剂量。 现有的许多文献没有涉及这些问题。 初步研究表明，在饮用水中给予布洛芬可以促进接受腹部手术的小鼠的行为恢复。 本申请提出通过鉴定用于小鼠中急性、手术或炎性疼痛的额外或上级镇痛方案来扩展该工作。 这些数据应该揭示新的和实用的策略，以减轻术后疼痛的小鼠。

DESCRIPTION (provided by applicant): Recognizing and alleviating pain are common challenges in laboratory animal medicine and are mandated by the Animal Welfare Act and the Public Health Service Policy on the Use of Laboratory Animals. However, available data on effective post-surgical analgesia for rodents has been collected primarily by studying rats; relatively few studies specifically assess analgesic efficacy for clinical use in mice. The development of clinical approaches for veterinary medical management of mice has lagged behind the explosive expansion in the availability and scientific use of genetically modified strains of mice, particularly with respect to their increasing importance in studies requiring surgical manipulation. The need to identify efficacious analgesic regimens for mice will become even more imperative should the United States Department of Agriculture eventually amend its definition of "animal" to include the genus Mus. This application proposes to evaluate the efficacy of several oral analgesic regimens for treatment of acute, surgical, and inflammatory pain in mice. Oral administration of analgesic medications via the drinking water is advantageous in a research setting because it permits large numbers of animals to be treated efficiently and without additional manipulation. However, important considerations are to assure both that the therapeutic regimen has efficacy against the pain the animals are experiencing and that the animals voluntarily consume enough medication to achieve effective doses. Much of the available literature does not address these issues. Preliminary work indicates that ibuprofen administered in the drinking water promotes behavioral recuperation in mice that have undergone abdominal surgery. This application proposes to extend that work by identifying additional or superior analgesic regimens for acute, surgical or inflammatory pain in mice. The data should reveal new and practical strategies for relief of post-procedural pain in mice.