MOTION PROCESSING SYSTEM IN SCHIZOPHRENIA

精神分裂症的运动处理系统

• 批准号: 6950884
• 负责人: YUE CHEN
• 金额: $ 9.91万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2005-03-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6950884
• 关键词: behavioral /social science research tag; clinical research; eye movement disorders; human subject; motion perception; neural information processing; occipital lobe /cortex; psychophysics; schizophrenia; smooth pursuit eye movement; visual fixation; visual stimulus

DESCRIPTION: (Adapted from applicant's abstract) The investigators focus on the visual motion processing system was initially motivated by the finding that many schizophrenic patients and their biological relatives have impaired smooth pursuit, but other kinds of eye movements are normal. The selectiveness of eye tracking dysfunction suggested possible involvement of the cortical motion processing systems in schizophrenia. The investigators recent studies have shown that motion processing is indeed compromised in schizophrenia. In this application, the investigators propose to extend the study of motion processing systematically and parametrically in relation to schizophrenia. The goals are to assess motion processing and its roles at different levels of visual, cognitive and motor processing. In a series of studies, we propose to examine various aspects of motion processing, including velocity discrimination, both detection of and smooth pursuit responses to coherent motion, and perceptual grouping of motion-based signals for object recognition in schizophrenia patients. The motion-related visual, cognitive and oculomotor tasks serve as probes into the neural activities of the motion-sensitive brain areas, such as Middle Temporal Area and Medial Superior Temporal Area, as well as the brain areas that use motion| information (such as those in the parietal lobe). The results of these studies will generate a systematic characterization of the functional properties of the motion processing system as well as the parietal system in schizophrenia.

描述：（改编自申请人的摘要）研究者专注于 视觉运动处理系统最初的动机是发现， 许多精神分裂症患者和他们的生物学亲属的平滑功能受损， 但其他类型的眼球运动是正常的。眼睛的选择性 追踪功能障碍提示可能涉及皮质运动 精神分裂症的处理系统研究人员最近的研究表明， 表明精神分裂症的运动处理确实受到损害。在这 应用，研究人员建议扩展运动处理的研究 与精神分裂症的关系。这些目标是 为了评估运动处理及其在不同视觉水平上的作用， 认知和运动加工。在一系列的研究中，我们建议检查 运动处理的各个方面，包括速度辨别， 检测和平滑对相干运动的追踪响应，以及感知 用于精神分裂症中物体识别的基于运动的信号分组 患者与运动相关的视觉、认知和视觉任务作为 探索运动敏感脑区的神经活动，如 颞中区和内侧上级颞区，以及大脑 使用运动的区域|信息（如顶叶中的信息）。的 这些研究的结果将产生一个系统的特点， 运动处理系统以及顶骨的功能特性 精神分裂症的系统。