Conjunctive Representations in Cortex and Hippocampus
皮层和海马体的联合表征
基本信息
- 批准号:6819390
- 负责人:
- 金额:$ 31.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-05-10 至 2009-02-28
- 项目状态:已结题
- 来源:
- 关键词:amygdalabehavioral /social science research tagconditioningdiscrimination learningexcitatory aminoacidexperiencefluorescent in situ hybridizationgenetic regulationglutamate receptorhippocampushistologylaboratory ratlearningmemorymicroinjectionsneocortexneural information processingneural plasticityprotein structure functionregulatory genewestern blottings
项目摘要
DESCRIPTION (provided by applicant): The hippocampus is critical to what is termed declarative memory, our ability to consciously recall the events of our lives and to connect us with our past. It is also vulnerable to the deleterious effects of Alzheimer's dementia, stress, alcohol, stroke and other brain insults. Thus, this region of the brain continues to be a major target for gaining insights into the biological basis of memory that could lead to treatments, which could benefit people with memory disorders. The proposed research focuses on the hippocampus and to a lesser extend its interactions with the amygdala, with the goal of advancing our basic understanding of memory processes. Our specific aims are directed at three issues. In Aim 1 we will determine the contributions gluatamate receptors (NMDA and AMPA) in the hippocampus and amygdala make to the mnemonic and non-mnemonic functions of these regions by studying their roles in contextual fear conditioning and memory for context. In Aim 2 we will study memory maintenance processes that may be important for stabilizing hippocampal-dependent memories. This work is based on recent findings that for several days following a learning experience the resulting memory are vulnerable to disruption. These studies will investigate the hypothesis that glutamate receptor activation is critical to memory maintenance. In Aim 3 we focus on hippocampal dependent memories to investigate a novel hypothesis about the function of certain immediate early genes (lEGs), specifically, that one function of lEGs is to prime the memory system to facilitate the storage of subsequent events. It has two components: (a) experience at time 1 can influence the storage of a subsequent event experienced at time 2 and (b) this effect is mediated by lEGs. We propose experiments to test the implications of both components. This work will contribute to a more complete understanding of the basic mechanisms that support declarative memory and indirectly to the development of treatments to ameliorate memory disorders.
描述(由申请人提供):海马体对所谓的陈述性记忆至关重要,我们有意识地回忆生活中的事件并将我们与过去联系起来的能力。它也容易受到阿尔茨海默氏痴呆症、压力、酒精、中风和其他大脑损伤的有害影响。因此,大脑的这一区域仍然是深入了解记忆的生物学基础的主要目标,这可能导致治疗,这可能使记忆障碍患者受益。拟议中的研究重点是海马体,并在较小程度上与杏仁核的相互作用,目的是推进我们对记忆过程的基本理解。我们的具体目标针对三个问题。在目的1中,我们将通过研究海马和杏仁核中谷氨酸受体(NMDA和AMPA)在情境恐惧条件反射和情境记忆中的作用来确定它们对这些区域的记忆和非记忆功能的贡献。在目标2中,我们将研究记忆维持过程,这可能对稳定依赖于大脑的记忆很重要。这项工作是基于最近的研究结果,即在学习经历后的几天内,所产生的记忆容易受到破坏。这些研究将探讨谷氨酸受体激活对记忆维持至关重要的假设。在目标3中,我们专注于海马依赖性记忆,以研究关于某些立即早期基因(IEGs)功能的新假设,具体来说,IEGs的一个功能是启动记忆系统以促进后续事件的存储。它有两个组成部分:(a)在时间1的经历可以影响在时间2经历的后续事件的存储,以及(B)该效应由lEG介导。我们提出实验来测试这两个组件的影响。这项工作将有助于更全面地了解支持陈述性记忆的基本机制,并间接地开发改善记忆障碍的治疗方法。
项目成果
期刊论文数量(0)
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JERRY Weeks RUDY其他文献
JERRY Weeks RUDY的其他文献
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{{ truncateString('JERRY Weeks RUDY', 18)}}的其他基金
Immune Activation, Hippocampal IL-1beta, and Memory
免疫激活、海马 IL-1beta 和记忆
- 批准号:
7037518 - 财政年份:2002
- 资助金额:
$ 31.58万 - 项目类别:
Immune Activation, Hippocampal IL-1beta, and Memory
免疫激活、海马 IL-1beta 和记忆
- 批准号:
6623190 - 财政年份:2002
- 资助金额:
$ 31.58万 - 项目类别:
Immune Activation, Hippocampal IL-1beta, and Memory
免疫激活、海马 IL-1beta 和记忆
- 批准号:
6750725 - 财政年份:2002
- 资助金额:
$ 31.58万 - 项目类别:
Immune Activation, Hippocampal IL-1beta, and Memory
免疫激活、海马 IL-1beta 和记忆
- 批准号:
6898228 - 财政年份:2002
- 资助金额:
$ 31.58万 - 项目类别:
Immune Activation, Hippocampal IL-1beta, and Memory
免疫激活、海马 IL-1beta 和记忆
- 批准号:
6463919 - 财政年份:2002
- 资助金额:
$ 31.58万 - 项目类别:
CONJUNCTIVE REPRESENTATIONS IN CORTEX AND HIPPOCAMPUS
皮层和海马体的联合表征
- 批准号:
6086079 - 财政年份:2000
- 资助金额:
$ 31.58万 - 项目类别:
Conjunctive Representations in Cortex and Hippocampus
皮层和海马体的联合表征
- 批准号:
6892122 - 财政年份:2000
- 资助金额:
$ 31.58万 - 项目类别:
CONJUNCTIVE REPRESENTATIONS IN CORTEX AND HIPPOCAMPUS
皮层和海马体的联合表征
- 批准号:
6639162 - 财政年份:2000
- 资助金额:
$ 31.58万 - 项目类别:
CONJUNCTIVE REPRESENTATIONS IN CORTEX AND HIPPOCAMPUS
皮层和海马体的联合表征
- 批准号:
6539073 - 财政年份:2000
- 资助金额:
$ 31.58万 - 项目类别:
Conjunctive Representations in Cortex and Hippocampus
皮层和海马体的联合表征
- 批准号:
7032225 - 财政年份:2000
- 资助金额:
$ 31.58万 - 项目类别: