The Characterization And Treatment Of Children With Seve

七岁儿童的特征和治疗

• 批准号: 6824240
• 负责人: Ellen Leibenluft
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6824240
• 关键词: adolescence (12-20); behavioral /social science research tag; bipolar depression; child (0-11); child behavior disorders; child mental disorders; clinical research; clinical trials; conduct disorder; human subject; human therapy evaluation; interview; lithium; longitudinal human study; magnetic resonance imaging; mental disorder chemotherapy; mental disorder diagnosis; mood disorders; neuropsychological tests; patient oriented research; prefrontal lobe /cortex

Recently, researchers and clinicians have focused increased attention on a group of children with severe mood and behavioral dysregulation. These children are characterized by impairing symptoms that include abnormal baseline mood (i.e. irritability, anger, and/or sadness), hyperarousal (e.g. insomnia, agitation, distractibility), and increased reactivity to negative emotional stimuli. Because this syndrome shares many clinical features with bipolar disorder (BPD), there is considerable debate as to whether these children should be diagnosed with BPD. However, children with this syndrome lack the cardinal symptoms of BPD, and other DSM-IV diagnoses (ADHD, ODD, etc.) capture heterogeneous clinical populations that include many children who do not exhibit the symptoms noted above. Therefore, the goals of this project are 1) to identify reliably a group of children with severe mood and behavioral dysregulation in order to characterize them clinically and follow them longitudinally; 2) to conduct a double-blinded, placebo-controlled trial of lithium in this population; and 3) investigate whether lithium response, which has been associated with neurotrophic effects and with changes in phosphoinositide signaling in bipolar patients, has similar effects in this group of patients. Standardized interview modules and rating scales will be used to rate the clinical features of mood dysregulation. A double-blind, placebo-controlled trial of lithium will be conducted, and magnetic resonance spectroscopy (MRS) to measure NAA and mI will be preformed before and after treatment. Approximately 10 patients have completed the treatment trial, and MRS scans have been obtained. In addition, MRS scans and neuropsychological test data are being acquired from a sample of control adults and children to allow us to establish developmental norms for neurochemistry, and to explore associations between NAA levels and tests of prefrontal cortical function. Finally, a collaboration with Children's National Medical Center has been established in order to allow us to apply, in the setting of a tertiary care child psychiatric clinic, standardized instruments designed to characterize children with severe mood dysregulation.

最近，研究人员和临床医生越来越多地关注一组患有严重情绪和行为失调的儿童。这些儿童的特征是损害症状，包括异常的基线情绪（即易怒，愤怒和/或悲伤），过度觉醒（例如失眠，激动，注意力分散）和对负面情绪刺激的反应性增加。由于这种综合征与双相情感障碍（BPD）有许多共同的临床特征，因此对于这些儿童是否应诊断为BPD存在相当大的争议。然而，患有这种综合征的儿童缺乏BPD的主要症状，以及其他DSM-IV诊断（ADHD，ODD等）。捕获异质性临床人群，包括许多未表现出上述症状的儿童。因此，本项目的目标是：1）可靠地识别一组患有严重情绪和行为失调的儿童，以便对他们进行临床表征并对其进行纵向随访; 2）在该人群中进行锂的双盲，安慰剂对照试验;和3）研究锂反应，其与双相患者的神经营养作用和磷酸肌醇信号传导的变化有关，在这组患者中具有类似的作用。将使用标准化访谈模块和评定量表对情绪失调的临床特征进行评定。将进行锂的双盲、安慰剂对照试验，并在治疗前后进行磁共振波谱（MRS）以测量NAA和mI。大约10名患者完成了治疗试验，并获得了MRS扫描。此外，MRS扫描和神经心理学测试数据正在从控制成人和儿童的样本中获得，使我们能够建立神经化学的发育规范，并探索NAA水平和前额叶皮质功能测试之间的关联。最后，与国家儿童医疗中心建立了合作关系，使我们能够在三级儿童精神病诊所的环境中应用标准化工具，以确定患有严重情绪失调的儿童的特征。