Finite Element Methods for Fluid Structure Interactions Problems

流体结构相互作用问题的有限元方法

• 批准号: 2437933
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2437933
• 关键词: Finite; Element; Methods; Fluid; Structure

Blood flow through the placenta is crucial for materno-fetal exchange, and has critical implications for fetal wellbeing and lifelong health of the mother and child. However, little is known about placental blood flow due to the need to study it in utero, since placental structure is intrinsically linked to its in utero function, and animal models are of limited relevance.The aim of this thesis is to develop accurate and efficient biophysical computational models, comparing results to ex utero and in utero MRI data from both healthy and compromised pregnancies. The model will make use of sophisticated computational techniques capable of coupling the time-dependent geometry and hyper-elastic biomechanics of the placenta, giving an accurate simulation of the response of placental blood flow due to placental contractions.The model will provide a unique in silico test bed for scientists, enhancing their ability to detect compromised pregnancies with MRI and ultrasound, and ultimately improving pregnancy outcomes.

通过胎盘的血液流动对母胎交换至关重要，并对胎儿的健康和母婴的终身健康具有重要影响。然而，由于胎盘结构与其宫内功能有本质的联系，因此对胎盘血流的研究知之甚少。本论文的目的是开发准确有效的生物物理计算模型，将结果与健康和不良妊娠的宫外和宫内MRI数据进行比较。该模型将利用复杂的计算技术，能够耦合胎盘随时间变化的几何和超弹性生物力学，准确模拟胎盘收缩引起的胎盘血流反应。该模型将为科学家提供一个独特的硅胶试验台，增强他们通过核磁共振和超声波检测不良妊娠的能力，最终改善妊娠结局。