Optimising experiments for developing ion channel models

开发离子通道模型的优化实验

• 批准号: 2438154
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2438154
• 关键词: Optimising; experiments; developing; ion; channel

During this project we will design experiments to create predictive models of ion channel currents. Our aim is to produce shorter experiments which provide us with more information about the behaviour of ion channels under a variety of conditions. We will design new experiments to parameterise, test and select a model structure whilst accounting for experimental artefacts. In partnership with Victor Chang Cardiac Research Institute in Sydney Australia we will run our new experiments to allow a number of rounds of model refinement and experimental design.

在这个项目中，我们将设计实验来创建离子通道电流的预测模型。我们的目标是制作更短的实验，为我们提供更多关于各种条件下离子通道行为的信息。我们将设计新的实验来参数化，测试和选择模型结构，同时考虑实验人工制品。与澳大利亚悉尼Victor Chang心脏研究所合作，我们将进行新的实验，以进行几轮模型改进和实验设计。