High Field MRI: Limitations and Solutions

描述（由申请人提供）：本研究的长期目标是了解和开发工程解决方案，以解决在高磁场强度下磁共振成像（MRI）所遇到的困难。具体目标1：开发并验证一种方法，用于分析、量化和消除高场MR图像中由磁化率区域差异产生的静态场畸变伪影。这些信息将用于开发用于人体、动物和细胞解剖的高速功能性MRI和无畸变高场MRI的伪影校正技术。具体目标1：开发和验证模型和方法，以分析和量化发生在人类头部和身体的射频（RF）磁场扭曲，包括男性、女性、儿童和子宫内胎儿。这些分析将用于评估来自特定脉冲序列的区域射频功率沉积，以确保患者安全，并开发最小化射频不均匀性的方法。本着生物工程研究伙伴关系的精神，该提案将从明尼苏达大学磁共振研究中心（一个领先的7.0特斯拉全身MRI研究设施）、REMCOM（一个磁场建模软件公司）和国家高磁场实验室（一个包含17.8特斯拉MRI显微镜和11.7特斯拉小动物成像的国家研究实验室）获得专业知识和合作伙伴关系。这些研究的结果将有助于大量研究人员进行高速无畸变功能MRI、低场强和高场强下的解剖研究、动物和完整细胞的MR显微镜、患者安全性评估，以及在许多情况下，在高场强下被证明存在问题的回收技术。

DESCRIPTION (provided by applicant): The long-term objective of this research is to understand and develop engineering solutions to the difficulties presented to magnetic resonance imaging (MRI) at high magnetic field strength. Specific Aim 1: Develop and validate a methodology to analyze, quantify, and eliminate static field distortion artifacts produced in high field MR images by regional differences in magnetic susceptibility. This information will be used to develop artifact-correction techniques for high-speed functional MRI and distortion-free high field MRI of human, animal, and cellular anatomy. Specific Aim 1: Develop and validate models and methods to analyze and quantify radio frequency (RF) magnetic field distortions occurring in the human head and body of men, women, children, and fetuses in utero. These analyses will be used to evaluate regional RF power deposition from specific pulse sequences for patient safety and to develop methods to minimize RF inhomogeneity. In the spirit of the Bioengineering Research Partnership this proposal will draw expertise and partnership from the Center for Magnetic Resonance Research at the University of Minnesota (a premiere 7.0 Tesla whole body MRI research facility), REMCOM (a magnetic field modeling software company), and the National High Magnetic Field Laboratory (a National Research Laboratory incorporating 17.8 Tesla MRI microscopy and 11.7 Tesla small animal imaging). The results of these studies will aid a wide array of researchers in high speed distortion-free functional MRI, anatomical studies at both low and high field strengths, MR microscopy in animals and intact cells, evaluation of patient safety, and in many cases, reclaim techniques which have proven problematic at high field strengths.