High Field MRI: Limitations and Solutions

描述（由申请人提供）：本研究的长期目标是了解和开发工程解决方案，以解决高磁场强度下磁共振成像（MRI）的困难。具体目标1：开发并验证一种方法，用于分析、量化和消除高场MR图像中因磁化率区域差异而产生的静态场失真伪影。这些信息将用于开发人类、动物和细胞解剖学的高速功能MRI和无失真高场MRI的伪影校正技术。具体目标1：开发并验证模型和方法，以分析和量化男性、女性、儿童和子宫内胎儿的头部和身体中发生的射频（RF）磁场失真。这些分析将用于评价特定脉冲序列的局部射频功率沉积，以确保患者安全，并开发最大限度减少射频不均匀性的方法。本着生物工程研究伙伴关系的精神，该提案将借鉴明尼苏达大学磁共振研究中心的专业知识和伙伴关系（首个7.0特斯拉全身MRI研究设施），REMCOM（一家磁场建模软件公司），和国家高磁场实验室（国家研究实验室，包括17.8特斯拉MRI显微镜和11.7特斯拉小动物成像）。这些研究的结果将有助于广泛的研究人员在高速无失真的功能性MRI，解剖研究在低和高场强，MR显微镜在动物和完整的细胞，评估病人的安全性，并在许多情况下，回收技术已被证明是有问题的高场强。

DESCRIPTION (provided by applicant): The long-term objective of this research is to understand and develop engineering solutions to the difficulties presented to magnetic resonance imaging (MRI) at high magnetic field strength. Specific Aim 1: Develop and validate a methodology to analyze, quantify, and eliminate static field distortion artifacts produced in high field MR images by regional differences in magnetic susceptibility. This information will be used to develop artifact-correction techniques for high-speed functional MRI and distortion-free high field MRI of human, animal, and cellular anatomy. Specific Aim 1: Develop and validate models and methods to analyze and quantify radio frequency (RF) magnetic field distortions occurring in the human head and body of men, women, children, and fetuses in utero. These analyses will be used to evaluate regional RF power deposition from specific pulse sequences for patient safety and to develop methods to minimize RF inhomogeneity. In the spirit of the Bioengineering Research Partnership this proposal will draw expertise and partnership from the Center for Magnetic Resonance Research at the University of Minnesota (a premiere 7.0 Tesla whole body MRI research facility), REMCOM (a magnetic field modeling software company), and the National High Magnetic Field Laboratory (a National Research Laboratory incorporating 17.8 Tesla MRI microscopy and 11.7 Tesla small animal imaging). The results of these studies will aid a wide array of researchers in high speed distortion-free functional MRI, anatomical studies at both low and high field strengths, MR microscopy in animals and intact cells, evaluation of patient safety, and in many cases, reclaim techniques which have proven problematic at high field strengths.