High Field MRI: Limitations and Solutions

高场 MRI：局限性和解决方案

• 批准号: 6555575
• 负责人: MICHAEL B SMITH
• 金额: $ 135.16万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6555575
• 关键词: Aplysia; adult human (21+); bioengineering /biomedical engineering; bioimaging /biomedical imaging; body regions; clinical research; computer simulation; computer system design /evaluation; functional magnetic resonance imaging; head; human subject; image processing; laboratory rat; magnetic field; magnetic resonance imaging; method development; middle childhood (6-11); model design /development; neurons; patient oriented research; patient safety /medical error; radiowave radiation

DESCRIPTION (provided by applicant): The long-term objective of this research is to understand and develop engineering solutions to the difficulties presented to magnetic resonance imaging (MRI) at high magnetic field strength. Specific Aim 1: Develop and validate a methodology to analyze, quantify, and eliminate static field distortion artifacts produced in high field MR images by regional differences in magnetic susceptibility. This information will be used to develop artifact-correction techniques for high-speed functional MRI and distortion-free high field MRI of human, animal, and cellular anatomy. Specific Aim 1: Develop and validate models and methods to analyze and quantify radio frequency (RF) magnetic field distortions occurring in the human head and body of men, women, children, and fetuses in utero. These analyses will be used to evaluate regional RF power deposition from specific pulse sequences for patient safety and to develop methods to minimize RF inhomogeneity. In the spirit of the Bioengineering Research Partnership this proposal will draw expertise and partnership from the Center for Magnetic Resonance Research at the University of Minnesota (a premiere 7.0 Tesla whole body MRI research facility), REMCOM (a magnetic field modeling software company), and the National High Magnetic Field Laboratory (a National Research Laboratory incorporating 17.8 Tesla MRI microscopy and 11.7 Tesla small animal imaging). The results of these studies will aid a wide array of researchers in high speed distortion-free functional MRI, anatomical studies at both low and high field strengths, MR microscopy in animals and intact cells, evaluation of patient safety, and in many cases, reclaim techniques which have proven problematic at high field strengths.

描述(申请人提供)：这项研究的长期目标是了解并开发工程解决方案，以解决在高磁场强度下磁共振成像(MRI)所面临的困难。具体目标1：开发和验证一种分析、量化和消除高场磁共振图像中因磁化率区域差异而产生的静电场失真伪影的方法。这些信息将被用于开发人类、动物和细胞解剖学的高速功能MRI和无失真高场MRI的伪影校正技术。具体目标1：开发和验证模型和方法，以分析和量化发生在人类头部和身体内的男性、女性、儿童和胎儿在宫内的射频磁场失真。这些分析将用于评估特定脉冲序列的区域射频功率沉积，以确保患者安全，并开发将射频不均匀性降至最低的方法。本着生物工程研究伙伴关系的精神，这项建议将从明尼苏达大学磁共振研究中心(一家首屈一指的7.0特斯拉全身核磁共振研究设施)、Remcom(一家磁场建模软件公司)和国家高磁场实验室(一家包含17.8特斯拉核磁共振显微镜和11.7特斯拉小动物成像的国家研究实验室)获得专业知识和合作伙伴关系。这些研究的结果将在高速无失真功能MRI、低场强和高场强下的解剖学研究、动物和完整细胞的MR显微镜、患者安全性评估以及在许多情况下被证明在高场强下存在问题的回收技术方面为广泛的研究人员提供帮助。