Processing of Materials for Improved Biocompatibility

材料加工以提高生物相容性

• 批准号: 6908755
• 负责人: MICHAEL A. MATTHEWS
• 金额: $ 0.57万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6908755
• 关键词: antiseptic sterilization; bioengineering /biomedical engineering; biofilm; biomaterial compatibility; biomaterials; carbon dioxide; ceramics; endotoxins; implant; metals; polymers; prosthesis; surface property; thermodynamics

DESCRIPTION (provided by applicant): This Bioengineering Research Partnership (BRP) will conduct basic research to improve biocompatibility of materials used in biomedical devices such as prostheses and implants by providing a higher level of cleanliness and decontamination, while simultaneously providing sterilization. The BRP will determine the effectiveness of dense phase (liquid or compressed gas) carbon dioxide fluid technology for enhancing biocompatibility. The multidisciplinary partnership is led by the Department of Chemical Engineering at the University of South Carolina and includes two university partners; the Medical University of South Carolina and Clemson University, assisted by outside experts on surface preparation of implants and industrial applications of supercritical fluid based technology. A three-year BRP effort is proposed: Year 1 will confirm whether, and under what conditions, dense phase CO2 is an effective medium for sterilizing and cleaning common biomaterials and will focus on simple solid metallic, polymer, or ceramic coupons, using three typical microorganisms for tests of sterilization effectiveness and by processing samples that have been contaminated with known particulates (graphite, polyperfluoroethylene, and iron oxide) to determine the effectiveness of particulate removal and cleaning. Finally, tests to determine whether the materials treated with CO2, show improved resistance to bacterial adhesion and biofilm formation will be conducted. Year 2 research will focus on complex materials, namely flexible polymers (polyurethane and silicone rubber), as well as porous monoliths of titanium. Also in Year 2, the BRP will examine the material surface to search for adverse effects of CO2 processing, such as corrosion, pitting, and embrittlement. These experiments provide data needed for process optimization and permit comparison to known material/surface damage caused by existing cleaning and sterilization methods. Year 3 will focus on process design and optimization through the use of process design models and testing of representative devices (artificial joint, stent, and catheter) with CO2 under optimized conditions and determine the integrity and biocompatibility of the device. Also during Year 3, the ability of C02 processing to clean, decontaminate, and sterilize will be tested in vitro for material biocompatibility using cell culture methods and in vivo for histocompatibility using a subcutaneous implantation animal model.

描述（由申请人提供）：该生物工程研究合作伙伴关系（BRP）将进行基础研究，通过提供更高水平的清洁和去污，同时提供灭菌，来提高假肢和植入物等生物医学设备中使用的材料的生物相容性。 BRP 将确定密相（液体或压缩气体）二氧化碳流体技术在增强生物相容性方面的有效性。这一多学科合作伙伴关系由南卡罗来纳大学化学工程系领导，包括两所大学合作伙伴：南卡罗来纳医科大学和克莱姆森大学在植入物表面处理和超临界流体技术的工业应用方面得到外部专家的协助。建议开展为期三年的 BRP 工作： 第一年将确认密相二氧化碳是否以及在什么条件下是对常见生物材料进行灭菌和清洁的有效介质，并将重点关注简单的固体金属、聚合物或陶瓷试样，使用三种典型微生物测试灭菌效果，并通过处理被已知颗粒（石墨、聚全氟乙烯和氧化铁）污染的样品来确定颗粒的有效性 拆卸和清洁。最后，将进行测试以确定经过二氧化碳处理的材料是否显示出对细菌粘附和生物膜形成的抵抗力有所提高。 第二年的研究将重点关注复杂材料，即柔性聚合物（聚氨酯和硅橡胶）以及多孔钛整料。同样在第二年，BRP 将检查材料表面，以寻找 CO2 加工的不利影响，例如腐蚀、点蚀和脆化。这些实验提供了工艺优化所需的数据，并允许与现有清洁和灭菌方法造成的已知材料/表面损坏进行比较。 第三年将侧重于工艺设计和优化，通过使用工艺设计模型和在优化条件下用二氧化碳测试代表性装置（人工关节、支架和导管），并确定装置的完整性和生物相容性。同样在第3年期间，将使用细胞培养方法在体外测试CO 2 处理的清洁、去污和灭菌的能力，以测试材料的生物相容性，并使用皮下植入动物模型在体内测试组织相容性。

项目成果

Phase equilibrium for surfactant Ls-54 in liquid CO(2) with water and solubility estimation using the Peng-Robinson equation of state.

• DOI: 10.1016/j.fluid.2010.07.020
• 发表时间: 2010-11-25
• 期刊: Fluid phase equilibria
• 影响因子: 2.6
• 作者: Tarafa PJ;Matthews MA
• 通讯作者: Matthews MA

Compatibility of Medical-Grade Polymers with Dense CO(2).

• DOI: 10.1016/j.supflu.2007.05.002
• 发表时间: 2007-10
• 期刊: The Journal of supercritical fluids
• 作者: A. Jimenez;G. Thompson;M. Matthews;T. A. Davis;K. Crocker;J. Lyons;A. Trapotsis

Removing Endotoxin from Metallic Biomaterials with Compressed Carbon Dioxide-Based Mixtures.

使用压缩二氧化碳基混合物去除金属生物材料中的内毒素。

• DOI: 10.1016/j.supflu.2010.09.010
• 发表时间: 2011
• 期刊: The Journal of supercritical fluids
• 作者: Tarafa,PedroJ;Williams,Eve;Panvelker,Samir;Zhang,Jian;Matthews,MichaelA
• 通讯作者: Matthews,MichaelA