Simulaneous Dual Isotope SPECT w/Cross Talk Correction

带串扰校正的同步双同位素 SPECT

• 批准号: 6702591
• 负责人: ERIC C. FREY
• 金额: $ 35.21万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6702591
• 关键词: bioimaging /biomedical imaging; brain imaging /visualization /scanning; clinical research; diagnosis design /evaluation; heart imaging /visualization /scanning; human data; image enhancement; method development; single photon emission computed tomography

DESCRIPTION (provided by applicant): One unique feature of SPECT is the ability to use two pharmaceuticals labeled with different isotopes emitting photons with different energies to make simultaneous measurements of different physiological processes. Simultaneous acquisition of projection data from two isotopes has the advantage that it allows measurement of two potentially related processes (e.g., rest and stress perfusion or perfusion and receptor density) at the same time. This may add additional diagnostic information and, in addition, there are practical advantages such as increased patient throughput, elimination of problems with registration and results in common patient motion in the two studies. However, due to scatter in the patient and gamma camera and the poor energy resolution of conventional gamma cameras, dual isotope acquisition will result in cross talk contamination of the two sets of projection data. In this work we hypothesize that we can develop methods for simultaneously acquiring and reconstructing dual isotope images that can reduce the effects of this cross talk to the point where the images have diagnostic image quality close to that which they would have if acquired separately. We have chosen to focus on two specific applications: dual isotope Tc-99m/ TI-201 stress/rest myocardial perfusion SPECT and dual isotope Tc-99m/I-123 brain SPECT, with major emphasis on Tc-99m/TI-201 imaging. Toward this end we propose to: (1) Develop methods for optimizing and evaluating simultaneous TI-201/Tc-99m imaging (2) Develop and implement improved cross talk compensation methods for simultaneous dual isotope SPECT (3) Develop optimized acquisition methods for Tc-99m/TI-201 myocardial perfusion SPECT; (4) To evaluate these methods using simulated data and mathematical observers; (5) To evaluate simultaneous dual isotope Tc-99m/I-123 SPECT using phantom experiments and quantitative measures of image quality; and (6) To perform a clinical evaluation of simultaneous and separate acquisition of dual isotope rest/stress myocardial perfusion SPECT. Given the frequency with which this procedure is performed and the significant improvement in both patient comfort and clinical throughput, we believe this would have a substantial impact on clinical practice. We also will have developed techniques for simultaneous Tc-99m/I-123 brain imaging that may prove important as new I-123 and Tc-99m labeled brain agents are developed and marketed.

描述（由申请人提供）：SPECT的一个独特特点是能够使用两种标有不同同位素的药物，发射具有不同能量的光子，同时测量不同的生理过程。同时获取两种同位素的投影数据的优点是，它允许同时测量两个可能相关的过程（例如，休息和应激灌注或灌注和受体密度）。这可能会增加额外的诊断信息，此外，在两项研究中，有实际的优势，如增加患者吞吐量，消除注册问题和导致患者共同运动。然而，由于患者和伽马相机之间的散射以及常规伽马相机的能量分辨率较差，双同位素采集会导致两组投影数据的串扰污染。在这项工作中，我们假设我们可以开发同时获取和重建双同位素图像的方法，这些方法可以减少这种串扰的影响，使图像具有接近于单独获取的诊断图像质量的图像。我们选择专注于两个特定的应用：双同位素Tc-99m/TI-201应激/休息心肌灌注SPECT和双同位素Tc-99m/I-123脑SPECT，主要侧重于Tc-99m/TI-201成像。为此，我们建议：(1)开发优化和评估TI-201/Tc-99m同时成像的方法；(2)开发和实现改进的双同位素SPECT同时串扰补偿方法；(3)开发优化的Tc-99m/TI-201心肌灌注SPECT采集方法；(4)利用模拟数据和数学观察者对这些方法进行评价；(5)利用模体实验和定量测量图像质量的方法对同时双同位素Tc-99m/I-123 SPECT进行评价；(6)对同时和单独采集静息/应激心肌灌注双同位素SPECT进行临床评价。鉴于该手术的执行频率以及患者舒适度和临床吞吐量的显着改善，我们相信这将对临床实践产生重大影响。我们还将开发同时进行Tc-99m/I-123脑成像的技术，随着新的I-123和Tc-99m标记脑剂的开发和销售，这可能会证明是重要的。