Ultra-broad Semiconductor Source for High Resolution OCT

用于高分辨率 OCT 的超宽半导体源

• 批准号: 6783883
• 负责人: KEVIN J KNOPP
• 金额: $ 9.65万
• 依托单位: AHURA CORPORATION, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6783883
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; energy source; gastrointestinal imaging /visualization; histology; histopathology; image enhancement; light emission; optical tomography; packaging material; phantom model; physical property; semiconduction

DESCRIPTION (provided by applicant): Ahura Corporation and our collaborators intend to design, develop, test, and commercialize an ultra-broad bandwith semiconductor light source for ultra-high resolution optical coherence tomography (OCT). OCT is an exciting imaging technology emerging for non-invasive high-resolution imaging of tissue and the cells within. OCT is able to image and differentiate tissue, the micro-structural features of glands, cysts, epithelium, and plaques in blood vessels. OCT holds the promise of providing early detection and diagnosis of cancers and cardiovascular diseases. Our vision is that the development of semiconductor light sources for ultra-high resolution OCT can create a disruption in technology that will move ultra-high resolution OCT into the clinical marketplace. The Overall Aims of Our FastTrack Proposal: 1. Develop a novel single-chip semiconductor device which delivers high optical output power (>15 mW) across an ultra wide spectral range (>100 nm) centered at 1300 nm. The measured coherence function will approach that of an ideal Gaussian. Furthermore, the size and form factor will mimic a conventional "miniature" laser butterfly package; approximately 0.5"x approximately 1" 2. Demonstrate high resolution imaging with a commercial catheter-based imaging subsystem using our developed ultra-broadband light source. We will measure the axial and lateral resolution using test phantoms 3. Capture and compare high-resolution images of normal and pathological (excised) tissue with histology 4. Provide light sources pilot studies at clinical sites in the U.S and Europe Specific Phase 1 Aim: 1. Feasibility demonstration of a semiconductor light source at die level with >15 mW of power across a bandwidth of >100 nm at 1300 nm with relative intensity noise (RIN) <-120 dB/Hz. No light source meeting these criteria exists in the worldwide marketplace today.

描述（由申请人提供）： Ahura公司和我们的合作者打算设计、开发、测试和商业化一种用于超高分辨率光学相干断层扫描（OCT）的超宽带半导体光源。OCT是一种令人兴奋的成像技术，用于组织和细胞的非侵入性高分辨率成像。OCT能够成像和区分组织、腺体、囊肿、上皮和血管中斑块的微观结构特征。OCT有望提供癌症和心血管疾病的早期检测和诊断。我们的愿景是，超高分辨率OCT的半导体光源的开发可以创造一个技术突破，将超高分辨率OCT推向临床市场。 我们快速通道提案的总体目标： 1. 开发一种新型的单芯片半导体器件，在以1300 nm为中心的超宽光谱范围（>100 nm）内提供高光输出功率（>15 mW）。测量的相干函数将接近理想高斯的相干函数。此外，尺寸和形状因子将模仿传统的“微型”激光器蝶形封装;大约0.5“x大约1” 2. 使用我们开发的超宽带光源，通过基于导管的商用成像子系统演示高分辨率成像。我们将使用测试体模测量轴向和横向分辨率 3.捕获正常和病理（切除）组织的高分辨率图像并与组织学进行比较 4.在美国和欧洲的临床研究中心提供光源试点研究 第1阶段的具体目标： 1. 半导体光源在芯片级的可行性演示，在1300 nm处，在>100 nm的带宽上具有>15 mW的功率，相对强度噪声（RIN）<-120 dB/Hz。 在当今的世界市场上，没有满足这些标准的光源。