Examining the contribution of mutant DNMT3a in the development and sustained growth of Acute Myeloid Leukaemia

检查突变体 DNMT3a 在急性髓系白血病发生和持续生长中的贡献

• 批准号: nhmrc : GNT1145728
• 负责人: A/Pr Andrew Wei
• 金额: $ 82.09万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/examining-contribution-mutant-myeloid-leukaemia/1348707
• 关键词: Examining; contribution; mutant; DNMT3a; development

Experimental models of Acute Myeloid Leukaemia (AML) have been valuable tools for studying this cancer. Recent analysis of human cancer genomes identified novel mutated gene products implicated in AML. To study the involvement of these genes in the development and sustained growth of AML, we will generate new experimental models that express the mutated forms of these newly described genes. These studies will assist in the development of improved treatments for patients with AML.

急性髓系白血病(AML)的实验模型是研究这种癌症的有价值的工具。最近对人类癌症基因组的分析发现了与急性髓细胞白血病有关的新的突变基因产物。为了研究这些基因在AML的发展和持续生长中的作用，我们将建立新的实验模型，表达这些新描述的基因的突变形式。这些研究将有助于改进急性髓细胞白血病患者的治疗方法。