Inhalant Use/Dependence: Incidence and Comorbidity

描述（由申请人提供）：本提案寻求对吸入剂使用和依赖的流行病学研究的支持，包括发病率，决定因素，合并症，以及全国代表性家庭居民样本中药物滥用服务的利用。建议的研究重点是在辍学者、育龄妇女、少数民族群体和父母吸毒的儿童中吸入剂使用/依赖的程度和程度。将对最近多波全国药物滥用家庭调查和全国合并症调查的公共使用数据文件进行分析。吸入剂滥用已被描述为最普遍但最不为人所知的药物问题之一，特别是在青少年中。目前关于吸入剂使用的知识主要是基于吸入剂使用的流行程度。本研究的具体目标如下：(1)研究吸入剂起始的发生率和决定因素；(2)确定青少年、辍学者、育龄女性、少数民族和吸毒者儿童中吸入剂使用/依赖的模式和决定因素；(3)确定从吸入剂使用到其他非法药物使用的发展序列的亚组差异（女性、少数民族和多重或早发性吸毒者）。(4)探讨吸入剂依赖的自然过程、吸入剂使用者的亚型和吸入剂依赖的症状特征；(5)调查共病和药物滥用服务利用情况。拟议的分析将提供与吸入剂使用开始有关的发病率趋势和特征的估计。将审查特别小组使用/依赖吸入剂的模式和程度，以便更好地满足他们对预防或药物滥用服务的需要。还将确定易患精神病理学的吸入剂使用者亚组和服务不足的使用者。所产生的信息对于决策者预测吸入剂使用问题的潜在负担和规划提供服务至关重要。我们对吸入剂使用的自然过程的知识差距将为未来的研究指明。

DESCRIPTION (provided by applicant): This proposal seeks support for research on the epidemiology of inhalant use and dependence, including incidence, determinants, comorbidity, and substance abuse service utilization in nationally representative samples of household residents. The proposed research focuses on the extent and magnitude of inhalant use/dependence among school dropouts, females of childbearing ages, ethnic minority groups, and children of drug-using parents. Analyses will be performed on public use data files from multiple waves of recent National Household Surveys on Drug Abuse and the National Comorbidity Survey. Inhalant abuse has been described as one of the most pervasive yet least recognized drug problems, particularly among adolescents. Current knowledge about inhalant use is based primarily on the prevalence of inhalant "use." This proposed study addresses the following specific aims (1) to examine the incidence and determinants of inhalant initiation, (2) to determine the pattern and determinants of inhalant use/dependence among youths, school dropouts, females of childbearing ages, ethnic minority groups, and children of drug users, (3) to identify subgroup variation in the developmental sequence of inhalant use to other illicit drug use (females, ethnic minority groups, and multiple or early-onset drug users), (4) to explore the natural course of inhalant dependence, subtypes of inhalant users, and symptom profiles of inhalant dependence, and (5) to examine comorbidity and substance abuse service utilization. The proposed analysis will provide estimates of incidence trends and the characteristics related to onset of inhalant use. The pattern and magnitude of inhalant use/dependence by special subgroups will be examined so that their needs for prevention or substance abuse services can be better served. Subgroups of inhalant users vulnerable for psychopathology and underserved users will also be identified. The information generated will be vital to policy makers in predicting the potential burden of inhalant use problems and planning service delivery. Gaps in our knowledge of the natural course of inhalant use will be specified for future research.