Epdemiology of Non-Medical Prescription Anagesic Use

描述（由研究者提供）：本修订后的R 01申请要求支持研究一个重要且不断增长但研究不足的药物使用问题，即非医疗处方镇痛药使用（NMPAU）。我们试图揭示新的性别差异的流行病学NMPAU和相关的问题，为青少年和成人。我们建议对2002-2005年全国药物使用和健康调查（NSDUH）的数据进行二次分析。有四个具体目标。第一个目的是研究首次NMPAU发病率和决定因素的性别差异，包括发病趋势、启动风险期和最近启动的决定因素。第二个目的是确定非医疗处方镇痛药使用者（NMPAU）中多药使用的模式、顺序和相关性的性别差异，包括注射药物使用、多药使用和从第一个NMPAU到其他药物使用（例如可卡因、海洛因和其他处方药）的发展顺序。第三个目的是研究NMPAU疾病和其他物质使用障碍的患病率和相关性的性别差异，包括NMPAU疾病的最近趋势。第四个目标是调查NMPAUs在利用药物滥用治疗服务和认为需要药物滥用治疗方面的性别差异，包括接受治疗服务的地点、接受治疗的主要滥用药物、认为需要治疗的主要滥用药物以及利用治疗服务的障碍。这些拟议的分析将增加新的研究结果的文献中关于性别差异的发病率，患病率和相关的NMPAU和相关的问题（多药使用的顺序，注射吸毒，滥用和依赖，服务利用的模式，服务利用的障碍）。他们将有重要的影响，早期识别NMPAUs，预防和治疗措施的设计，估计治疗需求，并为未来的研究产生假设。将确定注射吸毒、多种毒品使用或药物依赖可能性增加的NMPAU亚组以及服务不足的NMPAU，以进行早期预防或有针对性地改善其获得药物滥用治疗服务的机会。这些发现对于决策者预测NMPAU相关问题的潜在负担至关重要。

DESCRIPTION (provided by investigator): This revised R01 application requests support to study a significant and growing but understudied drug use problem, non-medical prescription analgesic use (NMPAU). We seek to shed new light on gender differences in the epidemiology of NMPAU and associated problems for both adolescents and adults. We propose to conduct secondary analyses of data from 2002-2005 National Surveys on Drug Use and Health (NSDUH). There are four specific aims. The first aim is to examine gender differences in the incidence and determinants of first NMPAU, including incidence trends, risk periods for initiation, and determinants of recent initiation. The second aim is to determine gender differences in the patterns, sequences, and correlates of multidrug use among non-medical prescription analgesic users (NMPAUs), including injection drug use, multidrug use, and the developmental sequence from first NMPAU to other drug use (eg, cocaine, heroin, and other prescription drugs). The third aim is to examine gender differences in the prevalence and correlates of NMPAU disorders and the other substance use disorders, including recent trends of NMPAU disorders. The fourth aim is to investigate gender differences in the utilization of substance abuse treatment services and of the perceived need for substance abuse treatment among NMPAUs, including the location of treatment services received, the primary abused substance for which treatment was received, the primary abused substance with perceived need for treatment, and barriers to treatment service utilization. These proposed analyses will add new findings to the literature regarding gender differences in the incidence, prevalence, and correlates of NMPAU and associated problems (sequence of multidrug use, injection drug use, abuse and dependence, patterns of service utilization, and barriers to service utilization). They will have important implications for early identification of NMPAUs, designs of prevention and treatment initiatives, estimates of treatment needs, and generating hypotheses for future research. Subgroups of NMPAUs with an increased likelihood of injection drug use, multidrug use, or drug dependence, and underserved NMPAUs will be identified for early prevention or be targeted to improve their access to substance abuse treatment services. Such findings will be vital to policy makers in predicting the potential burden of NMPAU-related problems.