Full 360-degree Surface Imaging System for Small Animal

小动物360度全方位表面成像系统

• 批准号: 6833042
• 负责人: HUI LI
• 金额: $ 10万
• 依托单位: GENEX TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-16 至 2005-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6833042
• 关键词: Rodentias; bioengineering /biomedical engineering; biomedical equipment development; laboratory mouse; mathematical model; model design /development; optical tomography; phantom model; three dimensional imaging /topography; whole body imaging /scanning

DESCRIPTION (provided by applicant): We propose this SBIR effort to develop a unique three-dimensional (3D) surface imaging system for acquiring complete 3D surface profiles of a small animal undergoing in vivo optical tomography imaging procedures. The acquired 3D surface model of the small animal body provides accurate geometric boundary conditions for 3D reconstruction algorithms to produce precise 3D diffuse optical tomography (DOT) images. Advanced DOT algorithms require good a priori knowledge of the boundary geometry of the diffuse medium imaged in order to provide accurate forward models of light propagation within this medium. Original experimental DOT demonstrations for reconstructing absorbers, scatterers and fluorochromes all used phantoms or tissues that were confined to easily modeled geometries (such as a slab or a cylinder). In recent years several methods have been developed to model photon propagation through diffuse media with complex boundaries using finite solutions of the diffusion or transport equation (finite elements or differences) or more recently analytical methods based on the tangent-plane method. To fully exploit advantages of these sophisticated algorithms, accurate 3D boundary geometry of the subject must be extracted in a practical, real-time, and in vivo manner. To date, there is no known reported technique for extracting 3D dimensional boundaries with fully automated, accurate and real-time in vivo performance. We propose this SBIR project to address this pressing need in the small animal imaging community. The major innovation of this SBIR program is a new 3D imaging system design concept that will facilitate a speedy and convenient imaging configuration for acquiring a 3D model with complete 360-degree coverage of an animal body surface. Traditional 3D imaging methods of achieving complete surface coverage require either moving the image sensor or the animal body so that multiple 3D images from different viewing angles can be acquired. In in-vivo small animal optical imaging, the preferred way of performing image acquisitions is to obtain complete sets of images without moving either the camera or the animal. Specifically, our Phase I technical aims are listed below: Aim 1: Design and build functional prototype hardware of the proposed 3D imaging system; Aim 2: Develop 3D surface imaging reconstruction algorithms; Aim 3: Improve DOT algorithms to utilize the precise 3D geometric boundary data; Aim 4: Perform 3D and DOT imaging tests on small animal phantoms, assess prototype's performance; Aim 5: Develop a plan for integrating the 3D camera into a small animal DOT system in Phase II.

描述（由申请人提供）： 我们建议SBIR努力开发一种独特的三维（3D）表面成像系统，用于获取完整的3D表面轮廓的小动物进行体内光学断层成像程序。所获得的小动物身体的3D表面模型为3D重建算法提供精确的几何边界条件，以产生精确的3D漫射光学断层扫描（DOT）图像。 先进的DOT算法需要良好的先验知识的漫射介质成像的边界几何形状，以提供准确的前向模型的光在该介质中的传播。用于重建吸收体、散射体和荧光染料的原始实验DOT演示都使用了被限制在容易建模的几何形状（例如平板或圆柱体）的幻影或组织。近年来，已经开发了几种方法来模拟光子通过具有复杂边界的扩散介质的传播，使用扩散或输运方程的有限解（有限元或差分）或最近基于切平面方法的分析方法。为了充分利用这些复杂算法的优点，必须以实用、实时和体内的方式提取受试者的精确3D边界几何形状。迄今为止，还没有已知的用于提取具有全自动、准确和实时体内性能的3D尺寸边界的技术。 我们提出了这个SBIR项目，以解决小动物成像社区的这一迫切需求。该SBIR计划的主要创新是一种新的3D成像系统设计概念，将促进快速方便的成像配置，用于获取360度覆盖动物体表的3D模型。实现完整表面覆盖的传统3D成像方法需要移动图像传感器或动物身体，以便可以从不同视角获取多个3D图像。在体内小动物光学成像中，执行图像采集的首选方式是在不移动相机或动物的情况下获得完整的图像集。 具体而言，我们的第一阶段技术目标如下： 目标1：设计并构建三维成像系统的功能原型硬件; 目标2：开发三维表面成像重建算法; 目标3：改进DOT算法，使其能够利用精确的三维几何边界数据; 目的4：对小动物体模进行3D和DOT成像测试，评估样机的性能; 目标5：制定计划，将3D相机集成到第二阶段的小动物DOT系统中。