Energy Sensitive Digital Radiography

能量敏感数字射线照相

• 批准号: 6788483
• 负责人: Martin U Pralle
• 金额: $ 9.73万
• 依托单位: ION OPTICS, INC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-06 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6788483
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; computer program /software; digital imaging; electromagnetic radiation; radiation detector; radiography; surface coating

DESCRIPTION (provided by applicant): The long-term goals of this digital radiography project is the reduction of patient dose and production of images that demonstrate increased perspicuity for neoplasms and other lesions in comparison with available techniques. Currently, there are no modalities known to us that take advantage of the broad bremmstrahlung spectrum emitted by the typical x-ray unit and it's potential for tissue differentiation and contrast enhancement. A commercially available GE unit creates dual-energy photon sets by double exposing the patient, each exposure accomplished at a different kVp. Ion Optics will develop a modern radiation detector to record the energy of each photon. The required segregation into two or more data sets, labeled by energy, can then be accomplished by software. This algorithm would be adjustable, as per the characteristics of each patient, in a process akin to windowing. This approach requires only a single exposure, reducing motion artifacts to a minimum and is likely to lead to reduced patient exposure. Required instrumentation for acquiring data from many parallel channels has been developed for fast radiation detectors in nuclear physics. Phase I of this project will concentrate on proving the efficacy of high-pressure gas micro-pattern detectors. Such detectors are known to have good object and energy resolution with excellent linearity and SNR. The problem of parallax presented by having a thick gas absorber has been largely solved.

描述（由申请方提供）：该数字X线摄影项目的长期目标是减少患者剂量，并生成与现有技术相比可提高肿瘤和其他病变清晰度的图像。目前，我们还不知道有什么方法可以利用典型的X射线装置发出的宽韧致辐射谱，以及它在组织分化和对比度增强方面的潜力。市售的GE装置通过对患者进行两次曝光来产生双能量光子集，每次曝光以不同的kVp完成。Ion Optics将开发一种现代化的辐射探测器来记录每个光子的能量。所需的分离成两个或多个数据集，标记的能量，然后可以通过软件来完成。该算法将根据每个患者的特征在类似于窗口化的过程中进行调整。这种方法只需要一次曝光，将运动伪影减少到最低限度，并且可能导致患者曝光减少。在核物理学中，快速辐射探测器所需的从多个并行通道获取数据的仪器已经被开发出来。该项目的第一阶段将集中于证明高压气体微模式探测器的功效。已知这样的探测器具有良好的目标和能量分辨率，具有优异的线性度和SNR。由具有厚的气体吸收体所呈现的视差问题已经在很大程度上得到解决。