A Smart Polymer for Destination Cardiac Assist Devices

用于目的地心脏辅助设备的智能聚合物

• 批准号: 6789618
• 负责人: ROBERT B STEWART
• 金额: $ 9.98万
• 依托单位: ABIOMED, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6789618
• 关键词: auxiliary heart prosthesis; bioengineering /biomedical engineering; biomaterial development /preparation; biomaterial evaluation; biosensor device; biotechnology; clinical biomedical equipment; extended care; mechanical stress; monitoring device; patient care management; polymers

DESCRIPTION (provided by applicant): Cardiac assist devices are increasingly being used for long term support. As patient survival times increase substantially, device wear-out will increasingly play a role in the clinical management of patients with long term devices. Most of the extended use devices utilize flexing polymer membranes. Whereas, long term polymer abrasion may be a primary failure mode for these devices, the detection of polymer wear would be valuable information in the clinical management of patients. The ultimate objective of the research proposed here is to develop a smart polymer, which has embedded wear indicators. As the polymer is gradually abraded, a sensor onboard the device will detect different levels of wear, and a status of the device wear-out will be transmitted to the clinical management team. Detailed studies in Phase I will evaluate a smart polymer designed to indicate both a moderate and severe level of wear. The need for wear-out indicators, such as that developed here, will become increasing important as the number of patients with long term cardiac assist devices increases, and detailed device monitoring and management becomes logistically more difficult. Consequently, the incorporation of device wear-out, and other mission critical sensors should become prevalent in future generations of all long term cardiac assist devices.

描述（由申请人提供）： 心脏辅助设备越来越多地用于长期支持。随着患者生存时间大幅增加，设备磨损将越来越多地在长期设备患者的临床管理中发挥作用。大多数扩展设备都使用弯曲聚合物膜。尽管长期聚合物磨损可能是这些设备的主要故障模式，但在患者的临床管理中，聚合物磨损的检测将是有价值的信息。 这里提出的研究的最终目标是开发一种智能聚合物，该聚合物嵌入了磨损指标。随着聚合物的逐渐磨损，该设备在板上的传感器将检测到不同级别的磨损，并且设备磨损状态将传递给临床管理团队。第一阶段的详细研究将评估一种智能聚合物，旨在指示中等和严重的磨损水平。 随着长期心脏辅助设备的增加数量增加，对磨损指标的需求将变得越来越重要，并且详细的设备监控和管理变得更加困难。因此，在所有长期心脏辅助设备的未来子孙后代都应掺入设备磨损和其他任务关键传感器。