Deformable Mirror for Adaptive Optics Retinal Imaging

用于自适应光学视网膜成像的可变形镜

• 批准号: 6742040
• 负责人: Michael Albert Helmbrecht
• 金额: $ 9.99万
• 依托单位: IRIS AO, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6742040
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; imaging /visualization /scanning; optics; retina

DESCRIPTION (provided by applicant): Imaging the retina using adaptive optics (AO) to correct aberrations in the lens and cornea increases lateral resolution by a factor of three. Depth resolution for confocal systems increases by a factor of ten when correcting aberrations with AO. The increased resolution afforded by AO correction will improve early disease detection and will allow drug developers to quantitatively assess drug efficacy in vivo. Despite the large increase in resolution, widespread use of AO has been impeded by the high cost of the deformable-mirror (DM) wavefront corrector. Conventional DMs on the market today cost over $1000 per actuator. This is prohibitively expensive because ophthalmic AO systems require 100 actuators or more. The development of a compact, low-cost deformable mirror (DM) is crucial to the commercialization of AO imaging systems for the retina. For Phase I research, Iris AO will develop a low-cost (approximately $10 per actuator), high-stroke (20 mu/m), small aperture (8 mm) DM for use in adaptive-optics imaging of the retina. The microelectromechanical system (MEMS) DM will have at least 100 segments in the array, each with optical-surface errors smaller than 10 nm RMS. Later stages of research will develop an AO fundus camera for use in clinical settings.

描述（申请人提供）：使用自适应光学器件（AO）对视网膜进行成像以纠正晶状体和角膜中的像差，使横向分辨率增加了三倍。使用AO纠正畸变时，共聚焦系统的深度分辨率增加了十倍。 AO校正提供的分辨率增加将改善早期疾病检测，并使药物开发人员在体内定量评估药物疗效。尽管分辨率大幅增加，但AO的广泛使用受到了可变形摩尔（DM）波前校正器的高成本的阻碍。当今市场上的常规DMS每台执行器的成本超过1000美元。这非常昂贵，因为眼科AO系统需要100个或更多的执行器。紧凑的低成本可变形镜（DM）的发展对于视网膜的AO成像系统的商业化至关重要。对于第一阶段的研究，IRIS AO将开发低成本（每个执行器10美元），高速射击（20 mu/m），小 用于视网膜的自适应 - 启发式成像的光圈（8毫米）DM。微电机电 系统（MEMS）DM在阵列中至少具有100个段，每个段都具有小于10 nm rms的光学表面误差。后来的研究阶段将开发用于临床环境中的AO Felcus相机。