Deformable Mirror for Adaptive Optics Retinal Imaging

用于自适应光学视网膜成像的可变形镜

• 批准号: 6742040
• 负责人: Michael Albert Helmbrecht
• 金额: $ 9.99万
• 依托单位: IRIS AO, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6742040
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; imaging /visualization /scanning; optics; retina

DESCRIPTION (provided by applicant): Imaging the retina using adaptive optics (AO) to correct aberrations in the lens and cornea increases lateral resolution by a factor of three. Depth resolution for confocal systems increases by a factor of ten when correcting aberrations with AO. The increased resolution afforded by AO correction will improve early disease detection and will allow drug developers to quantitatively assess drug efficacy in vivo. Despite the large increase in resolution, widespread use of AO has been impeded by the high cost of the deformable-mirror (DM) wavefront corrector. Conventional DMs on the market today cost over $1000 per actuator. This is prohibitively expensive because ophthalmic AO systems require 100 actuators or more. The development of a compact, low-cost deformable mirror (DM) is crucial to the commercialization of AO imaging systems for the retina. For Phase I research, Iris AO will develop a low-cost (approximately $10 per actuator), high-stroke (20 mu/m), small aperture (8 mm) DM for use in adaptive-optics imaging of the retina. The microelectromechanical system (MEMS) DM will have at least 100 segments in the array, each with optical-surface errors smaller than 10 nm RMS. Later stages of research will develop an AO fundus camera for use in clinical settings.

描述(由申请人提供)：使用自适应光学(AO)对视网膜进行成像以矫正晶状体和角膜中的像差，可将横向分辨率提高三倍。当用声光校正像差时，共焦系统的深度分辨率提高到原来的十分之一。AO矫正提供的更高的分辨率将改善疾病的早期检测，并将使药物开发商能够定量评估体内的药物疗效。尽管分辨率有了很大的提高，但变形镜(DM)波前校正器的高成本阻碍了声光的广泛使用。如今市场上的传统DM每个执行器的价格超过1000美元。这是令人望而却步的昂贵，因为眼科AO系统需要100个或更多的执行器。开发一种紧凑、低成本的可变形反射镜(DM)对于视网膜光学成像系统的商业化至关重要。对于第一阶段的研究，Iris AO将开发一种低成本(每个执行器约10美元)、高冲程(20亩/米)、小型 孔径(8毫米)DM，用于视网膜的自适应光学成像。微电子机械 系统(MEMS)DM将在阵列中至少有100个段，每个段的光学表面误差小于10 nm RMS。研究的后期阶段将开发一种用于临床环境的眼底相机。