Hign Performance MEMS Deformable Mirror for Adaptive Optics Retinal Imaging

用于自适应光学视网膜成像的高性能 MEMS 可变形镜

• 批准号: 7903673
• 负责人: Michael Albert Helmbrecht
• 金额: $ 10万
• 依托单位: IRIS AO, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7903673
• 关键词: Affect; Age; Age related macular degeneration; Air; Area; Arts; Astronomy; Auditory; Award; Be++ element; Beds; Beryllium; Biomedical Engineering; Blindness; Caliber; Caring; Cells; Cellular Structures; Classification; Clinical; Collaborations; Computer Systems Development; Computers; Contact Lenses; Contracts; Coupled; Custom; Detection; Development; Devices; Diabetic Retinopathy; Disease; Electronics; Elements; Engineering; Exhibits; Eye; Eye diseases; Failure; Finite Element Analysis; Floods; Freedom; Frequencies; Fundus; General Population; Glaucoma; Goals; Grant; Hand; Heart; Housing; Human; Image; Imagery; Imaging Techniques; Individual; Industry; Iris; Laboratories; Laboratory Research; Laser Surgery; Lasers; Letters; Light; Maintenance; Manufacturer Name; Marketing; Measures; Mechanics; Medicine; Membrane; Mission; Neural Pathways; Operative Surgical Procedures; Ophthalmology; Ophthalmoscopes; Optical Coherence Tomography; Optics; Output; Patients; Performance; Phase; Photoreceptors; Play; Population; Population Study; Positioning Attribute; Process; Production; Property; Pupil; Quality of life; Reporting; Research; Research Personnel; Research Subjects; Resolution; Retina; Retinal; Retinal Cone; Retinal Diseases; Role; Scanning; Science; Semiconductors; Shapes; Side; Signal Transduction; Site; Small Business Innovation Research Grant; Stroke; Structure; Surface; System; Techniques; Technology; Testing; United States; Universities; Vision; Visual; Visual Acuity; Visual Pathways; Work; adaptive optics; base; cellular imaging; clinical practice; commercialization; computerized data processing; cost; design; design and construction; disease diagnosis; experience; falls; feeding; fighting; foot; imaging modality; improved; in vivo; innovative technologies; instrument; instrumentation; lens; liquid crystal; meetings; millimeter; next generation; novel; patient population; performance tests; programs; prototype; relating to nervous system; research study; response; retinal rods; sensor; somatosensory; technology development; tool; vision science

DESCRIPTION (provided by applicant): Iris AO is developing exciting technologies that enable in vivo cellular-level retinal imaging. The cutting-edge adaptive-optics (AO) systems Iris AO develops increases the axial and transverse resolution of retinal images 5 fold. AO is used to correct for the optical aberrations in the eye that drastically reduce the resolution of conventional retinal images. Deformable mirrors (DM), the enabling component in AO systems, correct aberration by changing shape to compensate for the aberrations. This Phase II SBIR is dedicated to building advanced Microelectromechanical Systems (MEMS) DMs for clinical retinal-imaging systems. Imaging systems with AO exist in but a few cutting edge research laboratories throughout the world. In all of these systems, the most limiting aspect is the DM. These systems use DMs originally designed for telescopes or other applications because these are all that are available. This SBIR will bring DMs specifically designed for retinal imaging into the hands of researchers and then into clinical retinal imaging systems. Developing clinical-ready DMs will bring the benefits of these advanced imaging techniques to the general population. Iris AO's comprehensive expertise from DM manufacturing to building AO retinal-imaging systems for daily use in studying retinal diseases at the cellular-level will drive a revolution in advanced imaging techniques. By bringing AO out of the lab and into the clinical setting, this technology will have profound benefits. Iris AO's goals parallel the NEI mission of gaining a better understanding of visual function and fighting debilitating eye diseases. Iris AO engineers have helped pioneer studies in early disease detection by looking at the retina with the unprecedented resolution afforded by AO. This proposal directly meets objectives laid out in the NEI National Plan by developing a critical component in AO systems that will be used in AO-equipped SLO and OCT systems. This research will develop the DM over two iterations, refining the manufacturing each step of the way. Finite element analysis, performance testing, and failure studies will feed into the design to create robust mirrors. The development will focus on clinically valuable mirrors by meeting the required correction performance and solving practical issues necessary to bring AO into the clinical setting. After the mirror is built and tested in an AO test bed, it will be integrated into an existing AO retinal imaging system to image photoreceptors. This exciting high-performance technology will enable in vivo imaging of cellular structure to be done on the general populace instead of hand-picked research subjects as is the practice today. Research from this SBIR will enable a powerful new tool for early retinal disease detection and better understanding of visual function. The resulting technology puts the ability to observe into the retina at the cellular level into the hands of clinicians, thereby allowing them to see the start of a retinal disease before debilitating damage has been done.

描述（由申请人提供）：IRIS AO正在开发令人兴奋的技术，这些技术使体内细胞水平的视网膜成像。尖端的自适应启发（AO）系统IRIS AO发展增加了视网膜图像5倍的轴向和横向分辨率。 AO用于校正眼睛中的光差，从而大大减少了传统视网膜图像的分辨率。可变形的镜子（DM），AO系统中的启用组件，通过更改形状来纠正畸变以补偿畸变。该II期SBIR致力于构建用于临床视网膜成像系统的高级微电动系统（MEMS）DMS。具有AO的成像系统存在，但全世界的一些尖端研究实验室。在所有这些系统中，最有限的方面是DM。这些系统使用最初为望远镜或其他应用设计的DMS，因为这些都可以使用。该SBIR将将专门设计用于视网膜成像的DMS纳入研究人员的手中，然后进入临床视网膜成像系统。开发临床准备就绪的DMS将把这些高级成像技术的好处带给普通人群。 IRIS AO从DM制造到建立AO视网膜成像系统的全面专业知识，用于在细胞级研究视网膜疾病时每天使用，将推动高级成像技术的革命。通过将AO带出实验室并进入临床环境，该技术将带来深远的好处。 Iris AO的目标与NEI的任务相似，即获得对视觉功能和抗击使人衰弱的眼部疾病的理解。 IRIS AO工程师通过AO提供了前所未有的决议，通过查看视网膜来帮助先锋研究早期疾病检测。该提案直接符合NEI国家计划中提出的目标，它通过在AO系统中开发重要组成部分，该组件将用于配备AO的SLO和OCT系统。这项研究将在两个迭代中开发DM，从而完善制造业的每个步骤。有限元分析，性能测试和故障研究将融入设计以创建强大的镜子。该开发将通过满足所需的校正绩效并解决将AO带入临床环境所需的实际问题，将重点放在临床上有价值的镜子上。在AO测试床中构建镜子和测试后，它将集成到现有的AO视网膜成像系统中，以形象感光体。这种令人兴奋的高性能技术将使细胞结构的体内成像能够像当今的实践一样，而不是手工挑选的研究对象进行。该SBIR的研究将为早期视网膜疾病检测和对视觉功能的更好理解提供强大的新工具。最终的技术使在临床医生的手中观察到视网膜进入视网膜的能力，从而使他们能够在破坏性损害之前看到视网膜疾病的开始。