Nanoparticle Coating System for Biomedical Applications

描述（由申请人提供）： SBIR第一阶段项目的目标是开发用于纳米颗粒沉积和纳米颗粒空间喷雾的新的专用设备。该设备将采用一种新的纳米颗粒沉积和喷涂方法。纳米结构涂层在医疗保健中具有许多高潜力的应用，包括极大改善医疗植入物（牙科和假体），防护服和设备，改善药物输送系统和生物传感器的潜力。纳米颗粒喷雾剂具有很高的潜力，新的杀虫剂，可能是非常重要的生物防御应用的主机。在设计本提案中的设备时将考虑两种应用：（1）植入涂层和（2）用于生物防御的纳米颗粒的空气传播。应用特定的系统将被设计为实现在植入物上的均匀沉积和纳米颗粒（<100 nm）的均匀气载分散。纳米结构材料正在医学和其他领域引发一场材料革命。然而，由于操纵纳米材料的困难，这些应用的大规模商业化仍然难以实现。这一困难与纳米颗粒的高比表面积和强凝聚力的特性有关，这对沉积过程中的颗粒传输提出了很大的挑战。第一阶段SBIR项目专门针对这一挑战。

DESCRIPTION (provided by applicant): The objective of this SBIR Phase I project is to develop new specialized equipment for nanoparticle deposition and for spatial spray of nanoparticles. This equipment will feature a novel method of nanoparticle deposition and spray. Nanostructured coatings have many high-potential applications in health care including the potential for greatly improved medical implants (dental and prosthesis), protective clothing and devices, improved drug delivery systems and biosensors. Nanoparticle sprays have high potential for new bactericides that could be very important for a host of biodefense applications. Two applications will be considered during the design of the equipment in the present proposal: (1) implant coatings and (2) airborne dispersion of nanoparticles for biodefense. Application- specific systems will be designed to achieve uniform deposition on implants and uniform airborne dispersion of nanoparticles (<100 nm). Nanostructured materials are leading to a materials revolution in both medical and the other realms. However, large-scale commercialization of the applications remains elusive due to the difficulties in manipulating nanoscale materials. The difficulty is associated with nanoparticle's peculiar properties of very high surface area and strong cohesion, which imposes big challenge to the particle transport in deposition processes. This Phase I SBIR project is specifically geared to address this challenge.