PRENATAL COCAINE EXPOSURE AND ATTENTIONAL DYSFUNCTION
产前接触可卡因和注意力功能障碍
基本信息
- 批准号:6619545
- 负责人:
- 金额:$ 59.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-06-01 至 2006-01-31
- 项目状态:已结题
- 来源:
- 关键词:G protein attention deficit disorder autoradiography behavior test behavioral /social science research tag catecholamines cingulate gyrus cocaine congenital disorders dopamine receptor drug abuse embryo /fetus toxicology female laboratory rat mother /embryo /fetus nutrition neurochemistry prefrontal lobe /cortex receptor coupling
项目摘要
DESCRIPTION (Adapted from applicant's abstract): Using a clinically relevant
animal model, the applicants' studies have revealed that rats exposed to
cocaine prenatally (IV) exhibit a selective impairment in two aspects of
attentional function, whereas many other cognitive functions appear spared. The
proposed studies are designed to test the hypothesis that: The type of
attentional impairment seen following prenatal cocaine exposure results from
alterations in catecholaminergic systems in prefrontal cortex (PFC) and/or
anterior cingulate cortex (ACC), and that the targeting of these systems with
potential therapeutic agents will ameliorate the attentional impairments. In
the first set of studies, they will assess various attentional functions as
well as the functional integrity of frontal dopaminergic (DA) and noradrenergic
(NE) systems in the same animals. For the NE system, they will measure the
density of alpha1 and alpha2 adrenoreceptors and NE transporter in PFC and ACC
(and control regions). Similarly, the functional integrity of DA circuitry in
ACC and PFC will be assessed by measures of D1, D2, and D3 receptor density,
the DA transporter, and coupling of D1 and D2 receptors to their associated G
proteins. In addition to providing new information about the effects of
prenatal cocaine exposure on attentional function and on NE and DA systems in
frontal cortex, these studies provide a unique opportunity to establish
functional relationships between observed cognitive and neural changes. This is
not possible with the more common approach of assessing behavioral and neural
changes in separate groups of animals, often exposed to cocaine via different
routes and doses, with very different handling and testing histories. In the
second set of experiments, the efficacy of putative therapeutic agents will be
examined. These studies will: (a) provide direct tests of putative links
suggested by the first set of experiments and (b) identify drugs that are
likely to be useful therapeutically. A final contribution of both sets of
studies is to further elucidate the roles of the PFC and ACC and their
catecholaminergic innervation in cognitive functioning. The use of tasks that
specifically tap various attentional functions (including in-depth analyses of
performance data), coupled with assessment of putative neural mechanisms in the
same animals, should provide new information concerning the roles of these
systems.
描述(改编自申请人摘要):使用临床相关
在动物模型中,申请人的研究揭示了暴露于
可卡因产前(IV)表现出两个方面的选择性损害,
注意力功能,而许多其他认知功能似乎幸免。的
拟议的研究旨在验证假设:
产前接触可卡因后观察到的注意力障碍
前额叶皮层(PFC)中的儿茶酚胺能系统的改变和/或
前扣带皮层(ACC),这些系统的目标与
潜在的治疗剂将改善注意力障碍。在
在第一组研究中,他们将评估各种注意力功能,
以及额叶多巴胺能(DA)和去甲肾上腺素能(NE)的功能完整性
(NE)在相同的动物中。对于NE系统,他们将测量
PFC和ACC中α 1和α 2肾上腺素受体和NE转运体的密度
(and控制区域)。同样,DA电路的功能完整性,
ACC和PFC将通过测量D1、D2和D3受体密度进行评估,
DA转运蛋白,以及D1和D2受体与其相关G
proteins.除了提供有关影响的新信息外,
产前可卡因暴露对注意功能和NE和DA系统的影响
这些研究提供了一个独特的机会,
观察到的认知和神经变化之间的功能关系。这是
不可能用更常见的方法来评估行为和神经
不同动物群体的变化,通常通过不同的途径接触可卡因,
途径和剂量,处理和测试历史非常不同。在
在第二组实验中,假定的治疗剂的功效将是
考察这些研究将:(a)直接检验假定的联系
和(B)鉴定
可能在治疗上有用。最后一个贡献的两套
研究的目的是进一步阐明PFC和ACC的作用及其
认知功能中的儿茶酚胺能神经支配。使用任务,
具体挖掘各种注意力功能(包括对
性能数据),再加上评估假定的神经机制,
同样的动物,应该提供有关这些作用的新信息,
系统.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
BARBARA J STRUPP其他文献
BARBARA J STRUPP的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('BARBARA J STRUPP', 18)}}的其他基金
Perinatal choline therapy in a mouse model of Down Syndrome & Alzheimer's Disease
唐氏综合症小鼠模型的围产期胆碱治疗
- 批准号:
7362953 - 财政年份:2008
- 资助金额:
$ 59.27万 - 项目类别:
Perinatal choline therapy in a mouse model of Down Syndrome & Alzheimer's Disease
唐氏综合症小鼠模型的围产期胆碱治疗
- 批准号:
7760908 - 财政年份:2008
- 资助金额:
$ 59.27万 - 项目类别:
Perinatal choline therapy in a mouse model of Down Syndrome & Alzheimer's Disease
唐氏综合症小鼠模型的围产期胆碱治疗
- 批准号:
8049067 - 财政年份:2008
- 资助金额:
$ 59.27万 - 项目类别:
Perinatal choline therapy in a mouse model of Down Syndrome & Alzheimer's Disease
唐氏综合症小鼠模型的围产期胆碱治疗
- 批准号:
7568186 - 财政年份:2008
- 资助金额:
$ 59.27万 - 项目类别:
Perinatal choline therapy in a mouse model of Down Syndrome & Alzheimer's Disease
唐氏综合症小鼠模型的围产期胆碱治疗
- 批准号:
8211029 - 财政年份:2008
- 资助金额:
$ 59.27万 - 项目类别:
PRENATAL COCAINE EXPOSURE AND ATTENTIONAL DYSFUNCTION
产前接触可卡因和注意力功能障碍
- 批准号:
6858753 - 财政年份:2002
- 资助金额:
$ 59.27万 - 项目类别:
PRENATAL COCAINE EXPOSURE AND ATTENTIONAL DYSFUNCTION
产前接触可卡因和注意力功能障碍
- 批准号:
6711679 - 财政年份:2002
- 资助金额:
$ 59.27万 - 项目类别:
PRENATAL COCAINE EXPOSURE AND ATTENTIONAL DYSFUNCTION
产前接触可卡因和注意力功能障碍
- 批准号:
6435444 - 财政年份:2002
- 资助金额:
$ 59.27万 - 项目类别:
FACTORS MODIFYING BEHAVIORAL TOXICITY OF LEAD AND PCB'S
改变铅和多氯联苯行为毒性的因素
- 批准号:
6106346 - 财政年份:1999
- 资助金额:
$ 59.27万 - 项目类别:
FACTORS MODIFYING BEHAVIORAL TOXICITY OF LEAD AND PCB'S
改变铅和多氯联苯行为毒性的因素
- 批准号:
6340932 - 财政年份:1999
- 资助金额:
$ 59.27万 - 项目类别:
相似海外基金
PET STUDIES IN ATTENTION DEFICIT DISORDER: ROLE OF DOPAMINE
注意力缺陷障碍的宠物研究:多巴胺的作用
- 批准号:
7375392 - 财政年份:2005
- 资助金额:
$ 59.27万 - 项目类别:
PET STUDIES IN ATTENTION DEFICIT DISORDER: ROLE OF DOPAMINE
注意力缺陷障碍的宠物研究:多巴胺的作用
- 批准号:
7203667 - 财政年份:2004
- 资助金额:
$ 59.27万 - 项目类别:
PET studies in Attention Deficit Disorder: Role of Dopamine
注意力缺陷障碍中的 PET 研究:多巴胺的作用
- 批准号:
7044307 - 财政年份:2003
- 资助金额:
$ 59.27万 - 项目类别:
SEX AND AGE DIFFERENCES IN ATTENTION DEFICIT DISORDER
注意力缺陷障碍的性别和年龄差异
- 批准号:
6538382 - 财政年份:2002
- 资助金额:
$ 59.27万 - 项目类别:
AUTOMATED ASSESSMENT OF CHILD ATTENTION DEFICIT DISORDER
儿童注意力缺陷障碍的自动评估
- 批准号:
6403939 - 财政年份:2001
- 资助金额:
$ 59.27万 - 项目类别:
ADULTS W/ ATTENTION DEFICIT DISORDER: FAMILIAL & BEHAVIORAL DISORDERS
患有注意力缺陷障碍的成年人:家族性
- 批准号:
6491969 - 财政年份:2001
- 资助金额:
$ 59.27万 - 项目类别:
SEX AND AGE DIFFERENCES IN ATTENTION DEFICIT DISORDER
注意力缺陷障碍的性别和年龄差异
- 批准号:
6294921 - 财政年份:2001
- 资助金额:
$ 59.27万 - 项目类别:
ADULTS W/ ATTENTION DEFICIT DISORDER: FAMILIAL & BEHAVIORAL DISORDERS
患有注意力缺陷障碍的成年人:家族性
- 批准号:
6348140 - 财政年份:2000
- 资助金额:
$ 59.27万 - 项目类别:
ADULTS W/ ATTENTION DEFICIT DISORDER: FAMILIAL & BEHAVIORAL DISORDERS
患有注意力缺陷障碍的成年人:家族性
- 批准号:
6206110 - 财政年份:1999
- 资助金额:
$ 59.27万 - 项目类别:
TESTING THE VALIDITY OF ADULT ATTENTION DEFICIT DISORDER
测试成人注意力缺陷障碍的有效性
- 批准号:
2698824 - 财政年份:1998
- 资助金额:
$ 59.27万 - 项目类别: